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    Agfg1 ArfGAP with FG repeats 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agfg1provided by RGD
    Official Full Name
    ArfGAP with FG repeats 1provided by RGD
    Primary source
    RGD:1560041
    See related
    EnsemblRapid:ENSRNOG00000015619 AllianceGenome:RGD:1560041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; GTPase activator activity; and metal ion binding activity. Predicted to be involved in acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Predicted to be located in cell projection; intracellular membrane-bounded organelle; and neuronal cell body. Predicted to be active in cytoplasmic vesicle. Orthologous to human AGFG1 (ArfGAP with FG repeats 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 242.7), Brain (RPKM 224.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agfg1 in Genome Data Viewer
    Location:
    9q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91572962..91630688)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84124845..84182615)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88607508..88663486)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small cysteine and glycine repeat-containing protein 6-like Neighboring gene uncharacterized LOC120094723 Neighboring gene keratin-associated protein 5-2-like Neighboring gene small cysteine and glycine repeat-containing protein 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain. Khidekel N, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15340146, Free PMC Article
    2. Lack of acrosome formation in Hrb-deficient mice. Kang-Decker N, et al. Science, 2001 Nov 16. PMID 11711676
    3. The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids. Kierszenbaum AL, et al. Biol Reprod, 2004 May. PMID 14724135
    4. Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Catena R, et al. Dev Biol, 2006 Aug 1. PMID 16765935
    5. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. Brockschnieder D, et al. J Neurosci, 2006 Jan 18. PMID 16421295, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC116375

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid nucleus differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid nucleus differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP domain and FG repeat-containing protein 1
    Names
    HIV-1 Rev-binding protein homolog
    arf-GAP domain and FG repeats-containing protein 1
    nucleoporin-like protein RIP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135596.2 → NP_001129068.1  arf-GAP domain and FG repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001129068.1

      Status: VALIDATED

      Source sequence(s)
      FM032550, FM042993, FM069945, FM075043, FM099288, FM122674, FN806187, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q4KLH5
      Related
      ENSRNOP00000111045.1, ENSRNOT00000021309.9
      Conserved Domains (3) summary
      PHA03247
      Location:409 → 559
      PHA03247; large tegument protein UL36; Provisional
      COG5347
      Location:8 → 309
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd08857
      Location:13 → 128
      ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      91572962..91630688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLH5.1 GenPept UniProtKB/Swiss-Prot:Q4KLH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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