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    Hook3 hook microtubule-tethering protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306548, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hook3provided by RGD
    Official Full Name
    hook microtubule-tethering protein 3provided by RGD
    Primary source
    RGD:1560960
    See related
    EnsemblRapid:ENSRNOG00000014275 AllianceGenome:RGD:1560960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Predicted to be located in centriolar satellite; cis-Golgi network; and pericentriolar material. Predicted to be part of FHF complex and HOPS complex. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 322.0), Lung (RPKM 272.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hook3 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72656929..72751696)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (65954293..66058812)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (70710347..70818789)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482515 Neighboring gene THAP domain containing 1 Neighboring gene ring finger protein 170 Neighboring gene farnesyltransferase, CAAX box, subunit alpha Neighboring gene protein-O-mannose kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynactin binding  
    enables dynein intermediate chain binding  
    enables dynein light chain binding  
    enables identical protein binding  
    enables microtubule binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Golgi localization  
    involved_in cytoplasmic microtubule organization  
    involved_in cytoskeleton-dependent intracellular transport  
    involved_in early endosome to late endosome transport  
    involved_in endosome organization  
    involved_in endosome to lysosome transport  
    acts_upstream_of_or_within interkinetic nuclear migration  
    involved_in interkinetic nuclear migration  
    involved_in lysosome organization  
    acts_upstream_of_or_within microtubule anchoring at centrosome  
    involved_in negative regulation of neurogenesis  
    acts_upstream_of_or_within neuronal stem cell population maintenance  
    acts_upstream_of_or_within protein localization to centrosome  
    involved_in protein localization to centrosome  
    involved_in protein localization to perinuclear region of cytoplasm  
    Component Evidence Code Pubs
    part_of FHF complex  
    part_of HOPS complex  
    located_in centriolar satellite  
    located_in centrosome  
    located_in cis-Golgi network  
    located_in cytoplasm  
    located_in microtubule  
    located_in pericentriolar material  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136098.1NP_001129570.1  protein Hook homolog 3

      See identical proteins and their annotated locations for NP_001129570.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A0A8I5ZWS4, A0A8I6AQA0, A6IVZ4
      Related
      ENSRNOP00000091293.2, ENSRNOT00000097055.2
      Conserved Domains (2) summary
      pfam05622
      Location:184709
      HOOK; HOOK protein
      cl41774
      Location:8160
      HkD_SF; Hook domain-containing proteins superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      72656929..72751696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094555.2XP_038950483.1  protein Hook homolog 3 isoform X1

      Conserved Domains (2) summary
      pfam05622
      Location:184546
      HOOK; HOOK protein
      cd22226
      Location:8160
      HkD_Hook3; Hook domain found in protein Hook 3 (Hook3) and similar proteins
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