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    Abcc5 ATP binding cassette subfamily C member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116721, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcc5provided by RGD
    Official Full Name
    ATP binding cassette subfamily C member 5provided by RGD
    Primary source
    RGD:70913
    See related
    EnsemblRapid:ENSRNOG00000029178 AllianceGenome:RGD:70913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrp5; Abcc5a
    Summary
    Predicted to enable several functions, including ABC-type xenobiotic transporter activity; glutathione transmembrane transporter activity; and heme transmembrane transporter activity. Involved in response to insulin and response to lipopolysaccharide. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 1797.5), Brain (RPKM 177.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Abcc5 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93975579..94071659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80473809..80567257)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84395982..84490215)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095699 Neighboring gene ribosomal protein S7, pseudogene 3 Neighboring gene uncharacterized LOC102547398 Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene presenilin associated, rhomboid-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC156604

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ABC-type xenobiotic transporter activity  
    enables ABC-type xenobiotic transporter activity  
    enables ABC-type xenobiotic transporter activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables carbohydrate derivative transmembrane transporter activity  
    enables carbohydrate derivative transmembrane transporter activity  
    enables efflux transmembrane transporter activity  
    enables efflux transmembrane transporter activity  
    enables glutathione transmembrane transporter activity  
    enables glutathione transmembrane transporter activity  
    enables heme transmembrane transporter activity  
    enables heme transmembrane transporter activity  
    enables heme transmembrane transporter activity  
    enables macromolecule transmembrane transporter activity  
    enables macromolecule transmembrane transporter activity  
    enables nucleotide binding  
    enables purine nucleotide transmembrane transporter activity  
    enables purine nucleotide transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in cAMP transport  
    involved_in cAMP transport  
    involved_in cGMP transport  
    involved_in cGMP transport  
    involved_in export across plasma membrane  
    involved_in export across plasma membrane  
    involved_in folate transmembrane transport  
    involved_in folate transmembrane transport  
    involved_in folate transmembrane transport  
    involved_in glutathione transmembrane transport  
    involved_in glutathione transmembrane transport  
    involved_in heme transmembrane transport  
    involved_in heme transmembrane transport  
    involved_in heme transmembrane transport  
    involved_in hyaluronan biosynthetic process  
    involved_in hyaluronan biosynthetic process  
    involved_in purine nucleotide transport  
    involved_in response to insulin PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in transmembrane transport  
    involved_in xenobiotic transport  
    involved_in xenobiotic transport  
    Component Evidence Code Pubs
    located_in Golgi lumen  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in endosome membrane  
    is_active_in membrane  
    located_in membrane  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 5
    Names
    ATP-binding cassette sub-family C (CFTR/MRP) member 5a
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
    ATP-binding cassette, subfamily C (CFTR/MRP), member 5
    multidrug resistance-associated protein 5
    XP_017453338.1
    XP_038943832.1
    XP_038943833.1
    XP_038943835.1
    XP_038943836.1
    XP_063126313.1
    XP_063126314.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433820.1NP_001420749.1  ATP-binding cassette sub-family C member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      A0A0G2K6R4, Q9QYM0
      UniProtKB/TrEMBL
      A6JSB4, G3V676
    2. NM_001433821.1NP_001420750.1  ATP-binding cassette sub-family C member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    3. NM_001433822.1NP_001420751.1  ATP-binding cassette sub-family C member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    4. NM_001433823.1NP_001420752.1  ATP-binding cassette sub-family C member 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    5. NM_001433824.1NP_001420753.1  ATP-binding cassette sub-family C member 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    6. NM_001433825.1NP_001420754.1  ATP-binding cassette sub-family C member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    7. NM_001433826.1NP_001420755.1  ATP-binding cassette sub-family C member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    8. NM_001433827.1NP_001420756.1  ATP-binding cassette sub-family C member 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    9. NM_001433828.1NP_001420757.1  ATP-binding cassette sub-family C member 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A1A5M8, F7EV50
    10. NM_001433829.1NP_001420758.1  ATP-binding cassette sub-family C member 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    11. NM_001433830.1NP_001420759.1  ATP-binding cassette sub-family C member 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
    12. NM_053924.2NP_446376.2  ATP-binding cassette sub-family C member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      A0A0G2K6R4, Q9QYM0
      UniProtKB/TrEMBL
      A6JSB4, G3V676
      Related
      ENSRNOP00000002316.7, ENSRNOT00000002316.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93975579..94071659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087904.2XP_038943832.1  ATP-binding cassette sub-family C member 5 isoform X1

      Conserved Domains (1) summary
      PLN03130
      Location:1001424
      PLN03130; ABC transporter C family member; Provisional
    2. XM_039087905.2XP_038943833.1  ATP-binding cassette sub-family C member 5 isoform X3

      Conserved Domains (1) summary
      cd18592
      Location:181467
      ABC_6TM_MRP5_8_9_D1; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, 8, and 9
    3. XM_039087908.2XP_038943836.1  ATP-binding cassette sub-family C member 5 isoform X5

      Related
      ENSRNOP00000039986.6, ENSRNOT00000048306.7
      Conserved Domains (1) summary
      PLN03232
      Location:100156
      PLN03232; ABC transporter C family member; Provisional
    4. XM_063270244.1XP_063126314.1  ATP-binding cassette sub-family C member 5 isoform X4

    5. XM_039087907.2XP_038943835.1  ATP-binding cassette sub-family C member 5 isoform X4

      Conserved Domains (1) summary
      PLN03232
      Location:100156
      PLN03232; ABC transporter C family member; Provisional
    6. XM_063270243.1XP_063126313.1  ATP-binding cassette sub-family C member 5 isoform X2

    7. XM_017597849.3XP_017453338.1  ATP-binding cassette sub-family C member 5 isoform X2

    RNA

    1. XR_010055932.1 RNA Sequence

    2. XR_010055931.1 RNA Sequence

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