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    Pnliprp2 pancreatic lipase related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117554, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pnliprp2provided by RGD
    Official Full Name
    pancreatic lipase related protein 2provided by RGD
    Primary source
    RGD:620793
    See related
    EnsemblRapid:ENSRNOG00000017982 AllianceGenome:RGD:620793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables galactolipase activity; phospholipase activity; and triacylglycerol lipase activity. Involved in several processes, including galactolipid catabolic process; response to food; and response to glucocorticoid. Located in extracellular space; neuron projection; and zymogen granule membrane. Orthologous to human PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 814.7), Liver (RPKM 243.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Pnliprp2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (267883906..267902572)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (257897766..257916434)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (279896973..279927600)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase-related protein 1 Neighboring gene sperm microtubule inner protein 5 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene uncharacterized LOC134485263

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables galactolipase activity  
    enables galactolipase activity PubMed 
    enables galactolipase activity  
    enables galactolipase activity  
    enables lipase activity PubMed 
    enables lipoprotein lipase activity  
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables phospholipase A1 activity  
    enables phospholipase activity PubMed 
    enables phospholipase activity  
    enables triacylglycerol lipase activity PubMed 
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in cellular defense response  
    acts_upstream_of_or_within cellular defense response  
    involved_in cholesterol homeostasis  
    involved_in fatty acid biosynthetic process  
    involved_in galactolipid catabolic process PubMed 
    involved_in galactolipid catabolic process  
    involved_in high-density lipoprotein particle remodeling  
    involved_in intestinal lipid catabolic process  
    acts_upstream_of_or_within intestinal lipid catabolic process  
    involved_in phosphatidylcholine catabolic process  
    involved_in phosphatidylcholine catabolic process  
    involved_in phospholipid catabolic process  
    involved_in phospholipid catabolic process  
    involved_in phospholipid catabolic process  
    involved_in phospholipid metabolic process PubMed 
    involved_in post-embryonic development PubMed 
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in response to food PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to lipid PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in zymogen granule membrane PubMed 
    located_in zymogen granule membrane  

    General protein information

    Preferred Names
    pancreatic lipase-related protein 2
    Names
    PL-RP2
    cytotoxic T lymphocyte lipase
    galactolipase
    secretory glycoprotein GP-3
    triacylglycerol lipase
    NP_476554.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057206.1NP_476554.1  pancreatic lipase-related protein 2 precursor

      See identical proteins and their annotated locations for NP_476554.1

      Status: PROVISIONAL

      Source sequence(s)
      L09216
      UniProtKB/Swiss-Prot
      P54318
      UniProtKB/TrEMBL
      A6JI68, D3ZX17
      Related
      ENSRNOP00000063609.4, ENSRNOT00000068119.5
      Conserved Domains (2) summary
      cd01759
      Location:370482
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:31367
      Lipase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      267883906..267902572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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