Rps6ka6 ribosomal protein S6 kinase A6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6ka6provided by RGD
Official Full Name: ribosomal protein S6 kinase A6provided by RGD
Primary source: RGD:1560817
See related: EnsemblRapid:ENSRNOG00000002592 AllianceGenome:RGD:1560817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560817
Summary: Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of ERK1 and ERK2 cascade; and negative regulation of mesoderm development. Predicted to be located in fibrillar center and mitochondrion. Predicted to be active in cytoplasm; nucleoplasm; and synapse. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 29.0), Kidney (RPKM 23.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq31

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (80537723..80638910, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (76353316..76454502, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (82641679..82743771, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesoderm development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-6

Names: ribosomal protein S6 kinase polypeptide 6

NP_001178650.1

EC 2.7.11.1

XP_008771565.2

EC 2.7.11.1

XP_008771566.2

EC 2.7.11.1

XP_038955653.1

EC 2.7.11.1

XP_038955659.1

EC 2.7.11.1

XP_063136084.1

EC 2.7.11.1

XP_063136085.1

EC 2.7.11.1

XP_063136086.1

EC 2.7.11.1

XP_063136087.1

EC 2.7.11.1

XP_063136088.1

EC 2.7.11.1

XP_063136089.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191721.2 → NP_001178650.1 ribosomal protein S6 kinase alpha-6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I6AQN6

Related

ENSRNOP00000102256.1, ENSRNOT00000147711.1

Conserved Domains (4) summary

smart00220
Location:190 → 447

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:194 → 508

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:543 → 829

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

pfam00069
Location:543 → 800

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

80537723..80638910 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280018.1 → XP_063136088.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/TrEMBL

A0A0G2JXA6
XM_039099725.2 → XP_038955653.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0A0G2JXA6, A0A8I6G3H3

Conserved Domains (2) summary

cd05582
Location:115 → 429

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:464 → 753

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_063280015.1 → XP_063136085.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A0A0G2JXA6
XM_063280019.1 → XP_063136089.1 ribosomal protein S6 kinase alpha-6 isoform X2

UniProtKB/TrEMBL

A0A0G2JXA6
XM_063280017.1 → XP_063136087.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/TrEMBL

A0A0G2JXA6

Related

ENSRNOP00000101596.1, ENSRNOT00000144181.1
XM_063280014.1 → XP_063136084.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0A0G2JXA6, A0A8I6G3H3
XM_008773343.3 → XP_008771565.2 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0A0G2JXA6, A0A8I6G3H3

Related

ENSRNOP00000070197.3, ENSRNOT00000081625.3

Conserved Domains (2) summary

cd05582
Location:115 → 429

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:464 → 753

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_008773344.3 → XP_008771566.2 ribosomal protein S6 kinase alpha-6 isoform X2

UniProtKB/TrEMBL

A0A0G2JXA6

Conserved Domains (2) summary

cd05582
Location:115 → 429

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:464 → 748

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_039099731.2 → XP_038955659.1 ribosomal protein S6 kinase alpha-6 isoform X4

UniProtKB/TrEMBL

A0A0G2JXA6

Related

ENSRNOP00000103416.1, ENSRNOT00000158353.1

Conserved Domains (2) summary

cd05582
Location:115 → 429

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:464 → 750

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
XM_063280016.1 → XP_063136086.1 ribosomal protein S6 kinase alpha-6 isoform X3

UniProtKB/TrEMBL

A0A0G2JXA6