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    Acer3 alkaline ceramidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499210, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acer3provided by RGD
    Official Full Name
    alkaline ceramidase 3provided by RGD
    Primary source
    RGD:1561254
    See related
    EnsemblRapid:ENSRNOG00000036866 AllianceGenome:RGD:1561254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phca; RGD1561254
    Summary
    Predicted to enable N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 172.5), Lung (RPKM 139.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Acer3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161915397..162017802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152504180..152606596, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163160987..163263621, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calpain 5 Neighboring gene olfactory marker protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Neighboring gene uncharacterized LOC134483758 Neighboring gene uncharacterized LOC134484906 Neighboring gene tsukushi, small leucine rich proteoglycan

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity  
    enables N-acylsphingosine amidohydrolase activity  
    enables calcium ion binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in Golgi membrane  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    alkaline ceramidase 3
    Names
    phytoceramidase, alkaline
    NP_001387992.1
    XP_038957015.1
    XP_063127309.1
    XP_063127312.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401063.1 → NP_001387992.1  alkaline ceramidase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I6D2, F1M6P3
      Related
      ENSRNOP00000019987.7, ENSRNOT00000019987.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161915397..162017802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101087.2 → XP_038957015.1  alkaline ceramidase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADP7, F1M6P3
      Related
      ENSRNOP00000091431.1, ENSRNOT00000105288.2
      Conserved Domains (1) summary
      pfam05875
      Location:9 → 287
      Ceramidase
    2. XM_063271239.1 → XP_063127309.1  alkaline ceramidase 3 isoform X2

      UniProtKB/TrEMBL
      A6I6D3
    3. XM_063271242.1 → XP_063127312.1  alkaline ceramidase 3 isoform X3

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