Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dync1li2provided by RGD
Official Full Name: dynein, cytoplasmic 1 light intermediate chain 2provided by RGD
Primary source: RGD:621130
See related: EnsemblRapid:ENSRNOG00000025791 AllianceGenome:RGD:621130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lic2; Dncli2
Summary: Enables identical protein binding activity. Involved in cellular response to nerve growth factor stimulus. Located in centrosome; kinetochore; and late endosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 519.4), Lung (RPKM 334.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (538207..561110)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (531783..554670)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (740007..762897)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIC1, through BicD2, is required for apical nuclear migration in neural progenitors. In newborn neurons, we observe specific roles for LIC1 in the multipolar to bipolar transition and glial-guided neuronal migration. In contrast, LIC2 contributes to a novel dynein role in the little-studied mode of migration, terminal somal translocation.
Title: Distinct roles for dynein light intermediate chains in neurogenesis, migration, and terminal somal translocation.
Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A).
Title: DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoplasmic dynein 1 light intermediate chain 2

Names: LIC-2 dynein light intermediate chain 53/55; LIC53/55; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398670.1 → NP_001385599.1 cytoplasmic dynein 1 light intermediate chain 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A096MKA1, Q5D023

Related

ENSRNOP00000029646.3, ENSRNOT00000034472.6

Conserved Domains (1) summary

pfam05783
Location:30 → 488

DLIC; Dynein light intermediate chain (DLIC)
NM_031026.3 → NP_112288.1 cytoplasmic dynein 1 light intermediate chain 2 isoform 2

See identical proteins and their annotated locations for NP_112288.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q62698

UniProtKB/TrEMBL

A0A096MKA1, A6JXV7

Conserved Domains (3) summary

cd00009
Location:46 → 100

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam05783
Location:30 → 493

DLIC; Dynein light intermediate chain (DLIC)

cl21455
Location:218 → 294

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

538207..561110

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255054.5 → XP_006255116.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X1

UniProtKB/TrEMBL

A0A096MKA1

Related

ENSRNOP00000068268.2, ENSRNOT00000076604.4

Conserved Domains (2) summary

pfam05783
Location:30 → 474

DLIC; Dynein light intermediate chain (DLIC)

cl21455
Location:218 → 294

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039098021.2 → XP_038953949.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X2

Conserved Domains (1) summary

pfam05783
Location:30 → 367

DLIC; Dynein light intermediate chain (DLIC)