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    Arf2 ADP-ribosylation factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79119, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arf2provided by RGD
    Official Full Name
    ADP-ribosylation factor 2provided by RGD
    Primary source
    RGD:621271
    See related
    EnsemblRapid:ENSRNOG00000004807 AllianceGenome:RGD:621271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL17A (ARF like GTPase 17A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 108.4), Adrenal (RPKM 106.6) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See Arf2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89367843..89389644)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88867836..88889654)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92018562..92040335)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene uncharacterized LOC134480720 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene signal peptide peptidase like 2C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, et al. Mol Cell Biochem, 1996 Jun 7. PMID 8813705
    2. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846
    3. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304
    4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    5. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC114313

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor 2
    NP_077064.1
    XP_038942837.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024150.3 → NP_077064.1  ADP-ribosylation factor 2

      See identical proteins and their annotated locations for NP_077064.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P84082, Q4KM00
      UniProtKB/TrEMBL
      A0A8I5ZKF2, A6HJT6
      Related
      ENSRNOP00000077987.1, ENSRNOT00000113470.2
      Conserved Domains (1) summary
      cl40481
      Location:1 → 180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      89367843..89389644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086909.2 → XP_038942837.1  ADP-ribosylation factor 2 isoform X1

      UniProtKB/Swiss-Prot
      P84082, Q4KM00
      UniProtKB/TrEMBL
      A0A8I5ZKF2, A6HJT6
      Related
      ENSRNOP00000006483.4, ENSRNOT00000006483.7
      Conserved Domains (1) summary
      cl40481
      Location:1 → 180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84082.1 GenPept UniProtKB/Swiss-Prot:P84082

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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