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    Ubr2 ubiquitin protein ligase E3 component n-recognin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363188, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ubr2provided by RGD
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 2provided by RGD
    Primary source
    RGD:1593237
    See related
    EnsemblRapid:ENSRNOG00000015813 AllianceGenome:RGD:1593237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-leucine binding activity and histone H2A ubiquitin ligase activity. Predicted to be involved in several processes, including meiotic nuclear division; negative regulation of gene expression, epigenetic; and regulation of signal transduction. Predicted to act upstream of or within male meiosis I; spermatogenesis; and ubiquitin-dependent protein catabolic process. Predicted to be located in chromatin. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 321.8), Heart (RPKM 311.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubr2 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21480058..21559936)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13982427..14062315)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16003058..16080152)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transcriptional regulating factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene peripherin 2 Neighboring gene tubulin folding cofactor C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes. Crichton JH, et al. PLoS Genet, 2017 Jul. PMID 28708824, Free PMC Article
    2. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Kume K, et al. Genes Cells, 2010 Apr 1. PMID 20298436
    3. Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. MacLennan M, et al. Elife, 2017 Aug 14. PMID 28806172, Free PMC Article
    4. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2001 Dec. PMID 11689692, Free PMC Article
    5. Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2003 Nov. PMID 14585983, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-leucine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2A ubiquitin ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2A ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR2
    NP_001171542.2
    NP_001399747.1
    XP_038939744.1
    XP_038939748.1
    XP_063123425.1
    XP_063123426.1
    XP_063123427.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178071.2 → NP_001171542.2  E3 ubiquitin-protein ligase UBR2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D5MTH0
      Related
      ENSRNOP00000078618.2, ENSRNOT00000094973.2

    2. NM_001412818.1 → NP_001399747.1  E3 ubiquitin-protein ligase UBR2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5YBG5, D5MTH0
      Related
      ENSRNOP00000076741.1, ENSRNOT00000111742.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21480058..21559936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083820.2 → XP_038939748.1  E3 ubiquitin-protein ligase UBR2 isoform X4

      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    2. XM_063267357.1 → XP_063123427.1  E3 ubiquitin-protein ligase UBR2 isoform X5

    3. XM_039083816.2 → XP_038939744.1  E3 ubiquitin-protein ligase UBR2 isoform X1

      UniProtKB/TrEMBL
      D5MTH0
      Conserved Domains (5) summary
      cd00162
      Location:1113 → 1218
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222 → 300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1315 → 1735
      PRT6_C; Proteolysis_6 C-terminal
      cl17238
      Location:1112 → 1227
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_063267355.1 → XP_063123425.1  E3 ubiquitin-protein ligase UBR2 isoform X2

      UniProtKB/TrEMBL
      D5MTH0

    5. XM_063267356.1 → XP_063123426.1  E3 ubiquitin-protein ligase UBR2 isoform X3

    RNA

    1. XR_010054612.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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