Aebp1 AE binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aebp1provided by RGD
Official Full Name: AE binding protein 1provided by RGD
Primary source: RGD:1306922
See related: EnsemblRapid:ENSRNOG00000013720 AllianceGenome:RGD:1306922
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; carboxypeptidase activity; and collagen binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of collagen fibril organization. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 322.8), Uterus (RPKM 269.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (84951577..84962840)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (80738800..80748878)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (86101253..86111323)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
NOT involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen fibril organization	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adipocyte enhancer-binding protein 1

Names: aortic carboxypeptidase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100970.1 → NP_001094440.1 adipocyte enhancer-binding protein 1 precursor

See identical proteins and their annotated locations for NP_001094440.1

Status: PROVISIONAL

Source sequence(s)

BC133065

UniProtKB/Swiss-Prot

A2RUV9

UniProtKB/TrEMBL

A6IKQ1

Conserved Domains (4) summary

cd03869
Location:552 → 895

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:899 → 974

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

smart00231
Location:376 → 532

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:378 → 531

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

84951577..84962840

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273226.1 → XP_063129296.1 adipocyte enhancer-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

A2RUV9

UniProtKB/TrEMBL

A6IKQ1
XM_006251316.5 → XP_006251378.1 adipocyte enhancer-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A0H2UHL3, A6IKQ1

Related

ENSRNOP00000018846.8, ENSRNOT00000018846.8

Conserved Domains (4) summary

cd03869
Location:551 → 894

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:898 → 973

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

smart00231
Location:375 → 531

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:377 → 530

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.