Pigl phosphatidylinositol glycan anchor biosynthesis, class L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Piglprovided by RGD
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Lprovided by RGD
Primary source: RGD:620437
See related: EnsemblRapid:ENSRNOG00000003070 AllianceGenome:RGD:620437
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables N-acetylglucosaminylphosphatidylinositol deacetylase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 62.0), Thymus (RPKM 51.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47641478..47699200)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (47142160..47199892)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48774018..48831848)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme
Title: The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D10Got75 (e-PCR)
- UniSTS:113195

RH133086 (e-PCR)
- UniSTS:216369

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Names: PIG-L; phosphatidylinositol glycan, class L; phosphatidylinositol-glycan biosynthesis class L protein

NP_620256.1

EC 3.5.1.89

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.