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    Akap6 A-kinase anchoring protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64553, updated on 4-Jan-2025

    Summary

    Official Symbol
    Akap6provided by RGD
    Official Full Name
    A-kinase anchoring protein 6provided by RGD
    Primary source
    RGD:69412
    See related
    EnsemblRapid:ENSRNOG00000004841 AllianceGenome:RGD:69412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mAkap
    Summary
    Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of protein metabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 609.6), Brain (RPKM 313.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Akap6 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75919350..76359667)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (70184101..70624369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (73553111..73991992)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene neuronal PAS domain protein 3 Neighboring gene uncharacterized LOC102547735

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to cytokine stimulus PubMed 
    involved_in cellular response to epinephrine stimulus PubMed 
    involved_in negative regulation of adenylate cyclase activity PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth involved in cardiac muscle cell development PubMed 
    involved_in positive regulation of cell growth involved in cardiac muscle cell development PubMed 
    involved_in positive regulation of delayed rectifier potassium channel activity  
    involved_in positive regulation of potassium ion transmembrane transport  
    involved_in positive regulation of potassium ion transmembrane transport  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in positive regulation of translation PubMed 
    involved_in protein-containing complex localization PubMed 
    involved_in regulation of cAMP/PKA signal transduction PubMed 
    involved_in regulation of cardiac muscle cell contraction PubMed 
    involved_in regulation of membrane repolarization  
    involved_in regulation of membrane repolarization  
    involved_in regulation of relaxation of cardiac muscle PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum PubMed 
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    part_of calcium channel complex  
    part_of calcium channel complex  
    located_in caveola PubMed 
    located_in cytoplasm PubMed 
    located_in intercalated disc PubMed 
    located_in junctional sarcoplasmic reticulum membrane PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear membrane PubMed 
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleus PubMed 
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    part_of protein-containing complex PubMed 
    located_in sarcolemma PubMed 
    is_active_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    A-kinase anchor protein 6
    Names
    A kinase (PRKA) anchor protein 6
    AKAP-6
    PRKA6
    protein kinase A-anchoring protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022618.2NP_072140.2  A-kinase anchor protein 6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q9WVC7
      UniProtKB/TrEMBL
      A6HBI8
      Related
      ENSRNOP00000006562.3, ENSRNOT00000006562.5
      Conserved Domains (2) summary
      cd00176
      Location:9601187
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02488
      Location:7831056
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      75919350..76359667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594343.3XP_017449832.1  A-kinase anchor protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9WVC7
      UniProtKB/TrEMBL
      G3V6M0
    2. XM_039112889.2XP_038968817.1  A-kinase anchor protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIZ8
      Related
      ENSRNOP00000091441.1, ENSRNOT00000111927.2
      Conserved Domains (2) summary
      cd00176
      Location:9611188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02488
      Location:783887
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. XM_017594342.3XP_017449831.1  A-kinase anchor protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9WVC7
      UniProtKB/TrEMBL
      G3V6M0
    4. XM_063262448.1XP_063118518.1  A-kinase anchor protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q9WVC7
      UniProtKB/TrEMBL
      A6HBI8
    5. XM_063262449.1XP_063118519.1  A-kinase anchor protein 6 isoform X2

      UniProtKB/Swiss-Prot
      Q9WVC7
      UniProtKB/TrEMBL
      A6HBI8
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