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    Sdhaf4 succinate dehydrogenase complex assembly factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdhaf4provided by RGD
    Official Full Name
    succinate dehydrogenase complex assembly factor 4provided by RGD
    Primary source
    RGD:1588998
    See related
    EnsemblRapid:ENSRNOG00000072946 AllianceGenome:RGD:1588998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in cellular respiration; mitochondrial respiratory chain complex II assembly; and positive regulation of succinate dehydrogenase activity. Predicted to act upstream of or within innate immune response. Predicted to be active in mitochondrion. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 87.2), Adrenal (RPKM 84.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sdhaf4 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (33904667..33912813, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (26408332..26416478, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (30243261..30251478, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene small ArfGAP 1 Neighboring gene family with sequence similarity 135, member A Neighboring gene uncharacterized LOC102553447

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of novel genes that mediate innate immunity using inbred mice. Yang IV, et al. Genetics, 2009 Dec. PMID 19805818, Free PMC Article
    2. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Van Vranken JG, et al. Cell Metab, 2014 Aug 5. PMID 24954416, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of succinate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate dehydrogenase assembly factor 4, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399405.1 → NP_001386334.1  succinate dehydrogenase assembly factor 4, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJB2
      Conserved Domains (1) summary
      pfam07896
      Location:62 → 104
      DUF1674; Protein of unknown function (DUF1674)

    2. NM_001399406.1 → NP_001386335.1  succinate dehydrogenase assembly factor 4, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJB3
      Related
      ENSRNOP00000104596.1, ENSRNOT00000127123.1
      Conserved Domains (1) summary
      pfam07896
      Location:79 → 121
      DUF1674; Protein of unknown function (DUF1674)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      33904667..33912813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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