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    Ubr7 ubiquitin protein ligase E3 component n-recognin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubr7provided by RGD
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 7provided by RGD
    Primary source
    RGD:1359144
    See related
    EnsemblRapid:ENSRNOG00000008108 AllianceGenome:RGD:1359144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359144
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Orthologous to human UBR7 (ubiquitin protein ligase E3 component n-recognin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 155.6), Spleen (RPKM 121.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubr7 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127663454..127683302)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121898613..121918480)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126636596..126656513)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene modulator of apoptosis 1 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene lysosomal enzyme trafficking factor Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene BTB domain containing 7 Neighboring gene cytochrome c oxidase subunit 8C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-10b-5p Regulates Neuronal Autophagy and Apoptosis Induced by Spinal Cord Injury Through UBR7. Liu S, et al. Neuroscience, 2024 Apr 5. PMID 38382692
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-10b-5p Regulates Neuronal Autophagy and Apoptosis Induced by Spinal Cord Injury Through UBR7.
      Title: MiR-10b-5p Regulates Neuronal Autophagy and Apoptosis Induced by Spinal Cord Injury Through UBR7.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94098

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase UBR7
    Names
    ubiquitin protein ligase E3 component n-recognin 7 (putative)
    NP_001007706.1
    XP_006240537.1
    XP_006240538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007705.1 → NP_001007706.1  putative E3 ubiquitin-protein ligase UBR7

      See identical proteins and their annotated locations for NP_001007706.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081966
      UniProtKB/TrEMBL
      A0A8I5ZQV0, Q642A8
      Related
      ENSRNOP00000080502.2, ENSRNOT00000095309.2
      Conserved Domains (2) summary
      cd15542
      Location:134 → 185
      PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
      pfam02207
      Location:46 → 113
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127663454..127683302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240475.5 → XP_006240537.1  putative E3 ubiquitin-protein ligase UBR7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9Q8, F7F1G3
      Related
      ENSRNOP00000010738.5, ENSRNOT00000010739.6
      Conserved Domains (2) summary
      cd15542
      Location:134 → 185
      PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
      pfam02207
      Location:56 → 113
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    2. XM_006240476.5 → XP_006240538.1  putative E3 ubiquitin-protein ligase UBR7 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9Q8
      Conserved Domains (2) summary
      cd15542
      Location:134 → 185
      PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
      pfam02207
      Location:56 → 113
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    Nucleotide Protein Strain
    Heading Accession and Version

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