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    Giot1 gonadotropin inducible ovarian transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Giot1provided by RGD
    Official Full Name
    gonadotropin inducible ovarian transcription factor 1provided by RGD
    Primary source
    RGD:620184
    See related
    EnsemblRapid:ENSRNOG00000051563 AllianceGenome:RGD:620184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 143.1), Spleen (RPKM 65.6) and 9 other tissues See more
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    Genomic context

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    See Giot1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10868517..10886965, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10215602..10236423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13104166..13122625, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 2 Neighboring gene uncharacterized LOC120093534 Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene vomeronasal 2 receptor, 53

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats. Terra Dos Santos ALR, et al. Exp Physiol, 2021 Dec. PMID 34713942
    2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, et al. Mol Endocrinol, 2001 Oct. PMID 11579202
    3. A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion. Nikulina K, et al. Biochem Biophys Res Commun, 2006 Sep 29. PMID 16904636
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats.
      Title: Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gonadotropin inducible ovarian transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133563.1 → NP_598247.1  gonadotropin inducible ovarian transcription factor 1

      See identical proteins and their annotated locations for NP_598247.1

      Status: PROVISIONAL

      Source sequence(s)
      AB047636
      UniProtKB/TrEMBL
      Q91XV2
      Conserved Domains (6) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:258 → 654
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:553 → 578
      zf-H2C2_2; Zinc-finger double domain
      pfam16278
      Location:508 → 533
      zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10868517..10886965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262950.1 → XP_063119020.1  gonadotropin inducible ovarian transcription factor 1 isoform X1

      Related
      ENSRNOP00000074725.3, ENSRNOT00000080491.3

    2. XM_063262949.1 → XP_063119019.1  gonadotropin inducible ovarian transcription factor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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