U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Map3k1 mitogen-activated protein kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116667, updated on 4-Jan-2025

    Summary

    Symbol
    Map3k1provided by RGD
    Full Name
    mitogen-activated protein kinase kinase kinase 1provided by RGD
    Primary source
    RGD:620966
    See related
    EnsemblRapid:ENSRNOG00000013177 AllianceGenome:RGD:620966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mekk1
    Summary
    Enables several functions, including JUN kinase kinase kinase activity; protein kinase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of signal transduction; positive regulation of viral transcription; and protein modification process. Predicted to be located in tight junction. Predicted to be part of filamentous actin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 167.6), Kidney (RPKM 149.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Map3k1 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (45081889..45150555, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (43348572..43414706, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43329516..43393203, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485836 Neighboring gene SET domain containing, pseudogene 1 Neighboring gene uncharacterized LOC102553935 Neighboring gene uncharacterized LOC102554057

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase binding PubMed 
    enables JUN kinase kinase kinase activity PubMed 
    enables JUN kinase kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables cytoskeletal protein binding  
    enables mitogen-activated protein kinase binding PubMed 
    enables mitogen-activated protein kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables sphingolipid binding PubMed 
    enables ubiquitin-protein transferase activity PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade  
    involved_in MAPK cascade PubMed 
    acts_upstream_of_or_within apoptotic mitochondrial changes  
    acts_upstream_of_or_within camera-type eye development  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within epithelial cell morphogenesis  
    acts_upstream_of_or_within eyelid development in camera-type eye  
    acts_upstream_of_or_within morphogenesis of an epithelial sheet  
    involved_in negative regulation of actin filament bundle assembly PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of JUN kinase activity PubMed 
    involved_in positive regulation of JUN kinase activity  
    involved_in positive regulation of MAP kinase activity PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of actin filament polymerization  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of viral transcription PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein polyubiquitination PubMed 
    acts_upstream_of_or_within regulation of cell migration  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    acts_upstream_of_or_within wound healing  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of filamentous actin  
    located_in membrane  
    located_in tight junction  
    located_in tight junction  

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 1
    Names
    MAPK/ERK kinase kinase 1
    MEK kinase 1
    MEKK 1
    mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
    NP_446339.2
    XP_038957510.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053887.2NP_446339.2  mitogen-activated protein kinase kinase kinase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1M778, H9BFG7
      Related
      ENSRNOP00000088035.2, ENSRNOT00000114100.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      45081889..45150555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101582.2XP_038957510.1  mitogen-activated protein kinase kinase kinase 1 isoform X1

      UniProtKB/TrEMBL
      F1M778, H9BFG7
      Conserved Domains (2) summary
      cd06630
      Location:12231490
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:430485
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
    External link. Please review our privacy policy.