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    Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Papss1provided by RGD
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by RGD
    Primary source
    RGD:1308081
    See related
    EnsemblRapid:ENSRNOG00000011311 AllianceGenome:RGD:1308081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adenylylsulfate kinase activity; protein homodimerization activity; and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 344.7), Brain (RPKM 246.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Papss1 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (222646103..222788475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (220040343..220114399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (236605695..236680772)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485686 Neighboring gene uncharacterized LOC108350108 Neighboring gene sphingomyelin synthase 2 Neighboring gene uncharacterized LOC134485969 Neighboring gene uncharacterized LOC120100944 Neighboring gene uncharacterized LOC134485970 Neighboring gene polysaccharide biosynthesis domain containing 1, pseudogene 2 Neighboring gene RNA, variant U1 small nuclear 6 Neighboring gene actin related protein 10, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1. Harjes S, et al. Acta Crystallogr D Biol Crystallogr, 2004 Feb. PMID 14747722
    2. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. Singh B, et al. J Biol Chem, 2003 Jan 3. PMID 12414806
    3. Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Kurogi K, et al. Biol Pharm Bull, 2012. PMID 23207770
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
    NP_001381988.1
    XP_063137732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395059.1 → NP_001381988.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K0L0, B2RYI8
      Related
      ENSRNOP00000071489.2, ENSRNOT00000085301.3
      Conserved Domains (2) summary
      cd00517
      Location:254 → 617
      ATPS; ATP-sulfurylase
      pfam01583
      Location:51 → 205
      APS_kinase; Adenylylsulphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      222646103..222788475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281662.1 → XP_063137732.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0L0, B2RYI8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106471.1: Suppressed sequence

      Description
      NM_001106471.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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