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    Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk2ap2provided by RGD
    Official Full Name
    cyclin-dependent kinase 2 associated protein 2provided by RGD
    Primary source
    RGD:1588883
    See related
    EnsemblRapid:ENSRNOG00000018391 AllianceGenome:RGD:1588883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle; regulation of microtubule cytoskeleton organization; and regulation of stem cell division. Predicted to be part of NuRD complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Orthologous to human CDK2AP2 (cyclin dependent kinase 2 associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 243.5), Kidney (RPKM 196.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk2ap2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210819155..210822604)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201391056..201393137)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219345638..219347709)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase pi 3 Neighboring gene calcium binding protein 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene aryl-hydrocarbon receptor-interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells. Deshpande AM, et al. Stem Cells Dev, 2012 Nov 1. PMID 22548356, Free PMC Article
    2. Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation. Liu Q, et al. Int J Biol Sci, 2013. PMID 23781148, Free PMC Article
    3. DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes. Terret ME, et al. Development, 2003 Nov. PMID 12944431
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 2-associated protein 2
    Names
    CDK2-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109498.1 → NP_001102968.1  cyclin-dependent kinase 2-associated protein 2

      See identical proteins and their annotated locations for NP_001102968.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6AG30, A6HYS8, A6HYS9, D4A033
      Conserved Domains (2) summary
      TIGR00601
      Location:5 → 107
      rad23; UV excision repair protein Rad23
      pfam09806
      Location:63 → 126
      CDK2AP; Cyclin-dependent kinase 2-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210819155..210822604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230902.5 → XP_006230964.1  cyclin-dependent kinase 2-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006230964.1

      UniProtKB/TrEMBL
      A0A8I6AG30, A6HYS7, A6HYS9
      Related
      ENSRNOP00000103148.1, ENSRNOT00000140166.1
      Conserved Domains (2) summary
      pfam07462
      Location:7 → 40
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
      pfam09806
      Location:74 → 107
      CDK2AP; Cyclin-dependent kinase 2-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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