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    Pou2f2 POU class 2 homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pou2f2provided by RGD
    Official Full Name
    POU class 2 homeobox 2provided by RGD
    Primary source
    RGD:621690
    See related
    EnsemblRapid:ENSRNOG00000055650 AllianceGenome:RGD:621690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oct2; 2-Oct
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 33.0), Thymus (RPKM 6.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pou2f2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89810153..89897560, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80682330..80769756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81966791..82049116, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene zinc finger protein 574 Neighboring gene uncharacterized LOC103691054 Neighboring gene U6 spliceosomal RNA Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oct-2 transcription factor binding activity and expression up-regulation in rat cerebral ischaemia is associated with a diminution of neuronal damage in vitro. Camós S, et al. Neuromolecular Med, 2014 Jun. PMID 24282026
    2. Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus. Dees WL, et al. J Stud Alcohol, 2005 Jan. PMID 15830901
    3. Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2. Habu Y, et al. Biochem Pharmacol, 2003 Sep 15. PMID 12963498
    4. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Corcoran LM, et al. Genes Dev, 1993 Apr. PMID 8096198
    5. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Scheidereit C, et al. Nature, 1988 Dec 8. PMID 2904654

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
      Title: CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
    2. Oct-2 expression and binding activity increase in the late phase of cerebral ischaemia. It is involved in reducing ischaemic-mediated neuronal injury.
      Title: Oct-2 transcription factor binding activity and expression up-regulation in rat cerebral ischaemia is associated with a diminution of neuronal damage in vitro.
    3. OCT2 efficiently translocates agmatine and must be considered for the control of agmatine levels.
      Title: Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).
    4. Oct 2 POU gene is a likely target by which alcohol can interfere with glial-neuronal interactions and interrupt LHRH secretion during prepubertal development.
      Title: Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus.
    5. It showed decreased basolateral organic anion and cation transport activity, accompanied by a specific decrease in rOAT1, rOAT3 and rOCT2 expression in hyperuricemic rat kidney.
      Title: Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spermidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mature B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 2, transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271204.2 → NP_001258133.2  POU domain, class 2, transcription factor 2

      See identical proteins and their annotated locations for NP_001258133.2

      Status: VALIDATED

      Source sequence(s)
      FQ225995, L25863
      UniProtKB/TrEMBL
      A0A8I6A6L7
      Conserved Domains (2) summary
      smart00352
      Location:179 → 253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284 → 337
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89810153..89897560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588679.3 → XP_017444168.1  POU domain, class 2, transcription factor 2 isoform X3

      Conserved Domains (3) summary
      smart00352
      Location:315 → 389
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:219 → 336
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:420 → 474
      Homeobox; Homeobox domain

    2. XM_039113041.2 → XP_038968969.1  POU domain, class 2, transcription factor 2 isoform X3

      Conserved Domains (3) summary
      smart00352
      Location:315 → 389
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:219 → 336
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:420 → 474
      Homeobox; Homeobox domain

    3. XM_039113091.2 → XP_038969019.1  POU domain, class 2, transcription factor 2 isoform X5

      Related
      ENSRNOP00000107534.1, ENSRNOT00000147093.1
      Conserved Domains (3) summary
      smart00352
      Location:305 → 379
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:209 → 326
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:410 → 464
      Homeobox; Homeobox domain

    4. XM_063266973.1 → XP_063123043.1  POU domain, class 2, transcription factor 2 isoform X10

    5. XM_039113129.2 → XP_038969057.1  POU domain, class 2, transcription factor 2 isoform X6

      Conserved Domains (2) summary
      smart00352
      Location:294 → 368
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:399 → 453
      Homeobox; Homeobox domain

    6. XM_039113067.2 → XP_038968995.1  POU domain, class 2, transcription factor 2 isoform X4

      Conserved Domains (3) summary
      smart00352
      Location:310 → 384
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:203 → 331
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:415 → 469
      Homeobox; Homeobox domain

    7. XM_017588683.3 → XP_017444172.1  POU domain, class 2, transcription factor 2 isoform X8

      Related
      ENSRNOP00000089154.2, ENSRNOT00000103845.2

    8. XM_039112962.2 → XP_038968890.1  POU domain, class 2, transcription factor 2 isoform X1

      Conserved Domains (3) summary
      smart00352
      Location:327 → 401
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:231 → 348
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:432 → 486
      Homeobox; Homeobox domain

    9. XM_017588686.3 → XP_017444175.1  POU domain, class 2, transcription factor 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A150

    10. XM_017588685.3 → XP_017444174.1  POU domain, class 2, transcription factor 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A150
      Related
      ENSRNOP00000084371.2, ENSRNOT00000104344.2

    11. XM_039113188.2 → XP_038969116.1  POU domain, class 2, transcription factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A150
      Conserved Domains (2) summary
      smart00352
      Location:212 → 286
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:317 → 371
      Homeobox; Homeobox domain

    12. XM_063267339.1 → XP_063123409.1  POU domain, class 2, transcription factor 2 isoform X21

      UniProtKB/TrEMBL
      A0A8I6A6L7

    13. XM_063267045.1 → XP_063123115.1  POU domain, class 2, transcription factor 2 isoform X12

      Related
      ENSRNOP00000081328.2, ENSRNOT00000118587.2

    14. XM_063267312.1 → XP_063123382.1  POU domain, class 2, transcription factor 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I6A6L7
      Related
      ENSRNOP00000101660.1, ENSRNOT00000137877.1

    15. XM_063267012.1 → XP_063123082.1  POU domain, class 2, transcription factor 2 isoform X11

    16. XM_017588682.3 → XP_017444171.1  POU domain, class 2, transcription factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A150

    17. XM_039113307.2 → XP_038969235.1  POU domain, class 2, transcription factor 2 isoform X16

      Conserved Domains (3) summary
      smart00352
      Location:327 → 401
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:231 → 348
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:432 → 486
      Homeobox; Homeobox domain

    18. XM_063267524.1 → XP_063123594.1  POU domain, class 2, transcription factor 2 isoform X27

      UniProtKB/TrEMBL
      A0A8I5ZSA9

    19. XM_017588689.3 → XP_017444178.1  POU domain, class 2, transcription factor 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I5ZSA9

    20. XM_017588687.3 → XP_017444176.1  POU domain, class 2, transcription factor 2 isoform X19

      UniProtKB/TrEMBL
      A0A0G2KAN4
      Related
      ENSRNOP00000072745.3, ENSRNOT00000087572.3

    21. XM_063267218.1 → XP_063123288.1  POU domain, class 2, transcription factor 2 isoform X18

    22. XM_017588688.3 → XP_017444177.1  POU domain, class 2, transcription factor 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6A6L7

    23. XM_006228371.4 → XP_006228433.2  POU domain, class 2, transcription factor 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I6A6L7
      Conserved Domains (2) summary
      smart00352
      Location:201 → 275
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:306 → 359
      Homeobox; Homeobox domain

    24. XM_063267183.1 → XP_063123253.1  POU domain, class 2, transcription factor 2 isoform X17

      UniProtKB/TrEMBL
      A0A0G2K3R5, A0A0G2KAN4

    25. XM_063267129.1 → XP_063123199.1  POU domain, class 2, transcription factor 2 isoform X15

    26. XM_006228372.4 → XP_006228434.2  POU domain, class 2, transcription factor 2 isoform X24

      See identical proteins and their annotated locations for XP_006228434.2

      UniProtKB/TrEMBL
      A0A8I6A6L7
      Conserved Domains (2) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300 → 353
      Homeobox; Homeobox domain

    27. XM_039113050.2 → XP_038968978.1  POU domain, class 2, transcription factor 2 isoform X3

      Conserved Domains (3) summary
      smart00352
      Location:315 → 389
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:219 → 336
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:420 → 474
      Homeobox; Homeobox domain

    28. XM_039113004.2 → XP_038968932.1  POU domain, class 2, transcription factor 2 isoform X2

      Conserved Domains (3) summary
      smart00352
      Location:324 → 398
      POU; Found in Pit-Oct-Unc transcription factors
      PRK10263
      Location:228 → 345
      PRK10263; DNA translocase FtsK; Provisional
      pfam00046
      Location:429 → 483
      Homeobox; Homeobox domain

    29. XM_039078078.2 → XP_038934006.1  POU domain, class 2, transcription factor 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I6A6L7
      Conserved Domains (2) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300 → 354
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version

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