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    Serac1 serine active site containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serac1provided by RGD
    Official Full Name
    serine active site containing 1provided by RGD
    Primary source
    RGD:1565064
    See related
    EnsemblRapid:ENSRNOG00000017889 AllianceGenome:RGD:1565064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565064
    Summary
    Predicted to be involved in intracellular cholesterol transport and phosphatidylglycerol acyl-chain remodeling. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondria-associated endoplasmic reticulum membrane contact site; and mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 38.7), Testes (RPKM 31.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serac1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49025845..49061853, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46620741..46656801, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (46934499..46978264, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene uncharacterized LOC134482645 Neighboring gene uncharacterized LOC134482650 Neighboring gene uncharacterized LOC120099116 Neighboring gene uncharacterized LOC102551377 Neighboring gene general transcription factor IIH subunit 5 Neighboring gene TUB like protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Wortmann SB, et al. Nat Genet, 2012 Jun 10. PMID 22683713
    2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylglycerol acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein SERAC1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400935.1 → NP_001387864.1  protein SERAC1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6B543, D4ACP8
      Related
      ENSRNOP00000096974.1, ENSRNOT00000095436.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49025845..49061853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099712.2 → XP_038955640.1  protein SERAC1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A2J2, A6KP00, D4ACP8
      Related
      ENSRNOP00000087053.1, ENSRNOT00000098107.2
      Conserved Domains (1) summary
      cl21494
      Location:365 → 535
      Abhydrolase; alpha/beta hydrolases

    2. XM_063270670.1 → XP_063126740.1  protein SERAC1 isoform X2

      UniProtKB/TrEMBL
      D4ACP8

    3. XM_063270668.1 → XP_063126738.1  protein SERAC1 isoform X1

      UniProtKB/TrEMBL
      D4ACP8
      Related
      ENSRNOP00000101484.1, ENSRNOT00000131375.1

    4. XM_039099721.2 → XP_038955649.1  protein SERAC1 isoform X4

      Conserved Domains (1) summary
      cl21494
      Location:122 → 292
      Abhydrolase; alpha/beta hydrolases

    RNA

    1. XR_010055964.1 RNA Sequence

      Related
      ENSRNOT00000060527.7
    Nucleotide Protein Strain
    Heading Accession and Version

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