Rttn rotatin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rttnprovided by RGD
Official Full Name: rotatinprovided by RGD
Primary source: RGD:1306706
See related: EnsemblRapid:ENSRNOG00000038200 AllianceGenome:RGD:1306706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in centriole replication; centriole-centriole cohesion; and ciliary basal body organization. Predicted to act upstream of or within determination of left/right symmetry. Predicted to be located in centrosome. Predicted to be active in centriole and ciliary basal body. Orthologous to human RTTN (rotatin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 87.2), Spleen (RPKM 53.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q13

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (84495813..84673079)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (82220999..82398334)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (86071884..86247486)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole-centriole cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in ciliary basal body organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rotatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170436.2 → NP_001163907.2 rotatin

Status: VALIDATED

Source sequence(s)

FN802245, JAXUCZ010000018

Conserved Domains (1) summary

pfam14726
Location:16 → 112

RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning