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    Rsph1 radial spoke head component 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsph1provided by RGD
    Official Full Name
    radial spoke head component 1provided by RGD
    Primary source
    RGD:1307712
    See related
    EnsemblRapid:ENSRNOG00000057862 AllianceGenome:RGD:1307712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tsga2
    Summary
    Predicted to be involved in axoneme assembly and spermatid development. Predicted to be located in condensed nuclear chromosome and cytoskeleton. Predicted to be part of radial spoke head 1 and radial spoke head 3. Predicted to be active in motile cilium and nucleus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 52.5), Testes (RPKM 46.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rsph1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9343258..9361988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9341910..9360640, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9998698..10020719, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 3 Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene uncharacterized LOC120098980 Neighboring gene solute carrier family 37 member 1 Neighboring gene uncharacterized LOC120098916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects. Kott E, et al. Am J Hum Genet, 2013 Sep 5. PMID 23993197, Free PMC Article
    2. Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis. Tokuhiro K, et al. J Biol Chem, 2008 Jul 4. PMID 18453535
    3. Molecular cloning and characterization of meichroacidin (male meiotic metaphase chromosome-associated acidic protein). Tsuchida J, et al. Dev Biol, 1998 May 1. PMID 9578619
    4. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, et al. Anticancer Res, 2016 Jul. PMID 27354594
    5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head 1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head 3 ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head 1 homolog
    Names
    testis specific gene A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012176.1 → NP_001012176.1  radial spoke head 1 homolog

      See identical proteins and their annotated locations for NP_001012176.1

      Status: PROVISIONAL

      Source sequence(s)
      BC084704
      UniProtKB/TrEMBL
      A0A0G2K4W7, A0A0G2K6K4, A0A9K3Y812, F1LRG8, Q5XFW9
      Related
      ENSRNOP00000073201.2, ENSRNOT00000084726.3
      Conserved Domains (3) summary
      smart00698
      Location:88 → 109
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      COG4642
      Location:37 → 172
      COG4642; Uncharacterized conserved protein [Function unknown]
      pfam02493
      Location:67 → 89
      MORN; MORN repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9343258..9361988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279231.1 → XP_063135301.1  radial spoke head 1 homolog isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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