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    Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24211, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp1a1provided by RGD
    Official Full Name
    ATPase Na+/K+ transporting subunit alpha 1provided by RGD
    Primary source
    RGD:2167
    See related
    EnsemblRapid:ENSRNOG00000030019 AllianceGenome:RGD:2167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nkaa1b
    Summary
    Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; membrane hyperpolarization; and monoatomic cation transmembrane transport. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 7293.3), Heart (RPKM 1410.6) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Atp1a1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (191709311..191737414, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (189020722..189048826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (204003742..204032023, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 5 Neighboring gene immunoglobulin superfamily, member 3 Neighboring gene uncharacterized LOC103691652 Neighboring gene mab-21 like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables ADP binding PubMed 
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase binding  
    enables P-type potassium transmembrane transporter activity  
    enables P-type sodium:potassium-exchanging transporter activity  
    enables P-type sodium:potassium-exchanging transporter activity PubMed 
    enables P-type sodium:potassium-exchanging transporter activity  
    enables P-type sodium:potassium-exchanging transporter activity  
    enables ankyrin binding PubMed 
    enables metal ion binding  
    enables phosphatase activity  
    enables phosphatase activity  
    enables phosphatidylinositol 3-kinase binding PubMed 
    enables potassium ion binding PubMed 
    enables potassium ion binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein kinase binding PubMed 
    enables protein-folding chaperone binding PubMed 
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables sodium ion binding PubMed 
    enables sodium ion binding PubMed 
    enables sodium ion binding  
    enables steroid hormone binding  
    enables steroid hormone binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    Items 1 - 25 of 32
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to steroid hormone stimulus  
    involved_in cellular response to steroid hormone stimulus  
    involved_in energy coupled proton transmembrane transport, against electrochemical gradient PubMed 
    involved_in establishment or maintenance of transmembrane electrochemical gradient PubMed 
    involved_in establishment or maintenance of transmembrane electrochemical gradient  
    involved_in heart contraction  
    acts_upstream_of heart contraction  
    involved_in intracellular potassium ion homeostasis  
    involved_in intracellular potassium ion homeostasis  
    involved_in intracellular potassium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in membrane hyperpolarization PubMed 
    involved_in membrane repolarization  
    involved_in membrane repolarization  
    involved_in negative regulation of glucocorticoid biosynthetic process  
    acts_upstream_of_or_within negative regulation of glucocorticoid biosynthetic process  
    involved_in negative regulation of heart contraction  
    acts_upstream_of_or_within negative regulation of heart contraction  
    involved_in osmosensory signaling pathway  
    involved_in osmosensory signaling pathway  
    involved_in positive regulation of heart contraction  
    acts_upstream_of_or_within positive regulation of heart contraction  
    involved_in positive regulation of striated muscle contraction  
    acts_upstream_of_or_within positive regulation of striated muscle contraction  
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane PubMed 
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion transport PubMed 
    involved_in proton transmembrane transport  
    involved_in regulation of blood pressure  
    acts_upstream_of_or_within regulation of blood pressure  
    involved_in regulation of cardiac muscle cell contraction PubMed 
    involved_in regulation of sodium ion transport PubMed 
    involved_in regulation of the force of heart contraction  
    acts_upstream_of_or_within regulation of the force of heart contraction  
    involved_in relaxation of cardiac muscle PubMed 
    involved_in response to glycoside  
    NOT involved_in response to glycoside  
    involved_in response to glycoside  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within response to xenobiotic stimulus  
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion export across plasma membrane PubMed 
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion export across plasma membrane  
    involved_in sodium ion homeostasis  
    involved_in sodium ion transport PubMed 
    involved_in transmembrane transport PubMed 
    involved_in transmembrane transport  
    Items 1 - 25 of 54
    Items 1 - 20 of 37
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in T-tubule PubMed 
    located_in T-tubule  
    located_in T-tubule  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in axon  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in caveola PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endosome PubMed 
    located_in intercalated disc PubMed 
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in melanosome  
    located_in membrane PubMed 
    located_in membrane  
    located_in membrane  
    located_in organelle membrane  
    located_in organelle membrane  
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in postsynaptic density  
    part_of protein-containing complex  
    is_active_in sarcolemma  
    located_in sarcolemma PubMed 
    located_in sarcolemma  
    part_of sodium:potassium-exchanging ATPase complex  
    part_of sodium:potassium-exchanging ATPase complex PubMed 
    part_of sodium:potassium-exchanging ATPase complex  
    part_of sodium:potassium-exchanging ATPase complex  
    located_in sperm flagellum  
    located_in sperm flagellum  
    Items 1 - 20 of 37

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit alpha-1
    Names
    ATPase, Na+/K+ transporting, alpha 1 polypeptide
    ATPase, Na+K+ transporting, alpha 1
    Na(+)/K(+) ATPase alpha-1 subunit
    sodium pump subunit alpha-1
    NP_036636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012504.1NP_036636.1  sodium/potassium-transporting ATPase subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_036636.1

      Status: VALIDATED

      Source sequence(s)
      M14511
      UniProtKB/Swiss-Prot
      P06685, Q64609
      UniProtKB/TrEMBL
      A0A8I5Y5B0
      Related
      ENSRNOP00000045650.4, ENSRNOT00000040430.6
      Conserved Domains (6) summary
      smart00831
      Location:40114
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      COG4087
      Location:606732
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01106
      Location:291023
      ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
      pfam00122
      Location:134365
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:7991008
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam13246
      Location:427521
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      191709311..191737414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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