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    Zhx1 zinc fingers and homeoboxes 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zhx1provided by RGD
    Official Full Name
    zinc fingers and homeoboxes 1provided by RGD
    Primary source
    RGD:620010
    See related
    EnsemblRapid:ENSRNOG00000006412 AllianceGenome:RGD:620010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA binding activity. Involved in regulation of DNA-templated transcription. Located in nucleus. Orthologous to human ZHX1 (zinc fingers and homeoboxes 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 168.2), Brain (RPKM 158.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zhx1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91472193..91501984, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89582363..89611337, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97915280..97944787, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093813 Neighboring gene similar to human chromosome 8 open reading frame 76 Neighboring gene ribosomal protein S10, pseudogene 16 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene uncharacterized LOC134479909

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). Yamada K, et al. Biochem Biophys Res Commun, 2002 Sep 20. PMID 12237128
    2. Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Hirano S, et al. Gene, 2002 May 15. PMID 12062805
    3. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Kim SH, et al. Biochem Biophys Res Commun, 2007 Apr 6. PMID 17303076
    4. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Kawata H, et al. Biochem J, 2003 Aug 1. PMID 12741956, Free PMC Article
    5. Early changes in gene expression that influence the course of primary glomerular disease. Clement LC, et al. Kidney Int, 2007 Aug. PMID 17457373

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc fingers and homeoboxes protein 1
    Names
    zinc finger and homeodomain protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133620.2 → NP_598304.2  zinc fingers and homeoboxes protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q8R515
      UniProtKB/TrEMBL
      A6HRJ3, G3V6S9
      Conserved Domains (4) summary
      smart00389
      Location:665 → 716
      HOX; Homeodomain
      cd00086
      Location:468 → 523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785 → 821
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:98 → 150
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      91472193..91501984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594644.3 → XP_017450133.1  zinc fingers and homeoboxes protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R515
      UniProtKB/TrEMBL
      A6HRJ3, G3V6S9
      Related
      ENSRNOP00000079266.1, ENSRNOT00000100253.2
      Conserved Domains (4) summary
      smart00389
      Location:665 → 716
      HOX; Homeodomain
      cd00086
      Location:468 → 523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785 → 821
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:98 → 150
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    2. XM_063262951.1 → XP_063119021.1  zinc fingers and homeoboxes protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R515
      UniProtKB/TrEMBL
      A6HRJ3, G3V6S9
      Related
      ENSRNOP00000008454.2, ENSRNOT00000008454.6

    3. XM_017594643.3 → XP_017450132.1  zinc fingers and homeoboxes protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R515
      UniProtKB/TrEMBL
      A6HRJ3, G3V6S9
      Related
      ENSRNOP00000084155.1, ENSRNOT00000112281.2
      Conserved Domains (4) summary
      smart00389
      Location:665 → 716
      HOX; Homeodomain
      cd00086
      Location:468 → 523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785 → 821
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:98 → 150
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    4. XM_063262952.1 → XP_063119022.1  zinc fingers and homeoboxes protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R515
      UniProtKB/TrEMBL
      A6HRJ3, G3V6S9
      Related
      ENSRNOP00000081548.1, ENSRNOT00000117985.2

    RNA

    1. XR_010052934.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R515.1 GenPept UniProtKB/Swiss-Prot:Q8R515

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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