Sstr3 somatostatin receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sstr3provided by RGD
Official Full Name: somatostatin receptor 3provided by RGD
Primary source: RGD:620308
See related: EnsemblRapid:ENSRNOG00000007332 AllianceGenome:RGD:620308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SSTR; Smstr28
Summary: Predicted to enable G protein-coupled receptor activity; neuropeptide binding activity; and signaling receptor binding activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and cellular response to glucocorticoid stimulus. Predicted to be located in ciliary membrane and non-motile cilium. Predicted to be active in neuron projection and plasma membrane. Orthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 43.2), Thymus (RPKM 37.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111973049..111980250, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110092563..110109043, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119760881..119768082, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy increased mRNA levels of SSTR3 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model.
Title: Octreotide modulates the expression of somatostatin receptor subtypes in inflamed rat jejunum induced by Cryptosporidium parvum.
SSTR3 was significantly up-regulated after intracerebral hemorrhage, along with neuronal apoptosis.
Title: Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.
All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR3-4 was co-localized with insulin and pancreatic polypeptide.
Title: Somatostatin receptor 1-5; expression profiles during rat development.
the R-type calcium channel does not mediate the effects of somatostatin receptor 3 on insulin secretion in INS-1 cells.
Title: Characterization of voltage operated R-type Ca2+ channels in modulating somatostatin receptor subtype 2- and 3-dependent inhibition of insulin secretion from INS-1 cells.
study examined embryonic & postnatal development of SSTR3 expression in the hippocampal formation & its association with newly born & mature neurons in adult rats
Title: Developmental changes in frequency of the ciliary somatostatin receptor 3 protein.
SST-14 was cointernalized with SSTR3, was uncoupled from receptor, & was sorted into an endocytic degradation pathway, whereas octreotide was recycled as an intact peptide. Chronic stimulation of SSTR3 induced time-dependent downregulation of receptor.
Title: Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells.
All five SSTR are expressed in splanchnic blood vessels in normal and cirrhotic rats.
Title: Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats.
identification of a plasma membrane targeting sequence of rat somatostatin receptor subtype 3 [somatostatin receptor 3]
Title: Presence of a plasma membrane targeting sequence in the amino-terminal region of the rat somatostatin receptor 3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137873 (e-PCR)
- UniSTS:219960

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144457

D7Wox45 (e-PCR)
- UniSTS:518775

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables somatostatin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: somatostatin receptor type 3

Names: SS-3-R; SS3-R; SS3R; SSR-28; somatostatin receptor 28; somatostatin receptor subtype 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133522.2 → NP_598206.1 somatostatin receptor type 3

See identical proteins and their annotated locations for NP_598206.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P30936

UniProtKB/TrEMBL

A6HSL2

Related

ENSRNOP00000009612.2, ENSRNOT00000009612.5

Conserved Domains (2) summary

cd14964
Location:47 → 73

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 333

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily