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    Inhba inhibin subunit beta A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29200, updated on 9-Dec-2024

    Summary

    Official Symbol
    Inhbaprovided by RGD
    Official Full Name
    inhibin subunit beta Aprovided by RGD
    Primary source
    RGD:62074
    See related
    EnsemblRapid:ENSRNOG00000014320 AllianceGenome:RGD:62074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; peptide hormone binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to decreased oxygen levels; and positive regulation of DNA-templated transcription. Located in extracellular space. Part of inhibin A complex. Biomarker of congestive heart failure; myocardial infarction; retinal degeneration; and rheumatic heart disease. Orthologous to human INHBA (inhibin subunit beta A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 68.8), Uterus (RPKM 14.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Inhba in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (53787159..53810942, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (49091635..49111573, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (51894869..51919998, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482630 Neighboring gene uncharacterized LOC120097752 Neighboring gene U2 spliceosomal RNA Neighboring gene GLI family zinc finger 3 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables hormone activity  
    enables identical protein binding  
    enables peptide hormone binding  
    enables protein-containing complex binding PubMed 
    enables signaling receptor binding  
    enables type II activin receptor binding  
    Items 1 - 25 of 77
    Process Evidence Code Pubs
    involved_in GABAergic neuron differentiation  
    involved_in SMAD protein signal transduction PubMed 
    acts_upstream_of_or_within Sertoli cell differentiation  
    involved_in activin receptor signaling pathway  
    involved_in activin receptor signaling pathway  
    acts_upstream_of_or_within androgen metabolic process  
    acts_upstream_of_or_within androst-4-ene-3,17-dione biosynthetic process  
    involved_in autophagy PubMed 
    involved_in cardiac fibroblast cell development PubMed 
    involved_in cellular response to angiotensin PubMed 
    involved_in cellular response to cholesterol PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to oxygen-glucose deprivation PubMed 
    involved_in cytokine-mediated signaling pathway PubMed 
    involved_in endodermal cell differentiation  
    involved_in extrinsic apoptotic signaling pathway  
    involved_in eyelid development in camera-type eye  
    involved_in eyelid development in camera-type eye  
    acts_upstream_of_or_within gene expression  
    involved_in hair follicle development  
    involved_in hair follicle development  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
    involved_in hematopoietic progenitor cell differentiation  
    involved_in hematopoietic progenitor cell differentiation  
    involved_in hemoglobin biosynthetic process  
    involved_in hemoglobin biosynthetic process  
    acts_upstream_of_or_within lipid metabolic process  
    acts_upstream_of_or_within male gonad development  
    involved_in male gonad development  
    involved_in male gonad development  
    acts_upstream_of_or_within mesoderm formation  
    acts_upstream_of_or_within mesodermal cell differentiation  
    involved_in negative regulation of G1/S transition of mitotic cell cycle  
    involved_in negative regulation of G1/S transition of mitotic cell cycle  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of hair follicle development  
    involved_in odontogenesis  
    involved_in odontogenesis  
    involved_in ovarian follicle development  
    involved_in ovarian follicle development  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of ovulation  
    involved_in positive regulation of ovulation  
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase III PubMed 
    involved_in progesterone secretion  
    involved_in progesterone secretion  
    involved_in regulation of follicle-stimulating hormone secretion  
    involved_in regulation of follicle-stimulating hormone secretion  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to aldosterone PubMed 
    involved_in roof of mouth development  
    involved_in roof of mouth development  
    acts_upstream_of_or_within steroid biosynthetic process  
    acts_upstream_of_or_within steroid metabolic process  
    involved_in striatal medium spiny neuron differentiation  
    acts_upstream_of_or_within testosterone biosynthetic process  
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 77
    Component Evidence Code Pubs
    part_of activin A complex  
    part_of activin A complex  
    part_of enzyme activator complex  
    located_in extracellular region  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    part_of inhibin A complex PubMed 
    part_of inhibin A complex  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    inhibin beta A chain
    Names
    activin A
    activin beta-A chain
    inhibin beta A subunit
    inhibin beta-A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017128.2NP_058824.1  inhibin beta A chain preproprotein

      See identical proteins and their annotated locations for NP_058824.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P18331
      UniProtKB/TrEMBL
      A6K9B0
      Related
      ENSRNOP00000019272.2, ENSRNOT00000019272.7
      Conserved Domains (2) summary
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
      cl02928
      Location:56236
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      53787159..53810942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276286.1XP_063132356.1  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P18331
      UniProtKB/TrEMBL
      A6K9B0
    2. XM_063276287.1XP_063132357.1  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P18331
      UniProtKB/TrEMBL
      A6K9B0
    3. XM_008771712.4XP_008769934.1  inhibin beta A chain isoform X1

      See identical proteins and their annotated locations for XP_008769934.1

      UniProtKB/Swiss-Prot
      P18331
      UniProtKB/TrEMBL
      A6K9B0
      Conserved Domains (2) summary
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
      cl02928
      Location:56236
      TGFb_propeptide; TGF-beta propeptide
    4. XM_006254001.5XP_006254063.1  inhibin beta A chain isoform X1

      See identical proteins and their annotated locations for XP_006254063.1

      UniProtKB/Swiss-Prot
      P18331
      UniProtKB/TrEMBL
      A6K9B0
      Conserved Domains (2) summary
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
      cl02928
      Location:56236
      TGFb_propeptide; TGF-beta propeptide
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