Ano10 anoctamin 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ano10provided by RGD
Official Full Name: anoctamin 10provided by RGD
Primary source: RGD:1308260
See related: EnsemblRapid:ENSRNOG00000000219 AllianceGenome:RGD:1308260
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem16k; RGD1308260
Summary: Predicted to enable calcium-activated cation channel activity and intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 10. Orthologous to human ANO10 (anoctamin 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 159.2), Lung (RPKM 114.0) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130719177..130838243, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121841664..121960739, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130812941..130931021, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
NOT enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info