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    Rnf213 ring finger protein 213 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303735, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf213provided by RGD
    Official Full Name
    ring finger protein 213provided by RGD
    Primary source
    RGD:1308168
    See related
    EnsemblRapid:ENSRNOG00000029658 AllianceGenome:RGD:1308168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308168
    Summary
    Predicted to enable ATP hydrolysis activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; lipid droplet formation; and protein ubiquitination. Predicted to be located in cytoplasm and lipid droplet. Predicted to be active in cytosol and nucleolus. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 413.6), Adrenal (RPKM 287.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rnf213 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105154873..105254148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (104656329..104755669)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (108527351..108626372)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene solute carrier family 26 member 11 Neighboring gene uncharacterized LOC120095223 Neighboring gene endonuclease V Neighboring gene uncharacterized LOC103693491

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity  
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in defense response to bacterium  
    involved_in immune system process  
    involved_in lipid droplet formation  
    involved_in lipid ubiquitination  
    involved_in negative regulation of non-canonical Wnt signaling pathway  
    involved_in negative regulation of non-canonical Wnt signaling pathway  
    involved_in protein K63-linked ubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein ubiquitination  
    involved_in regulation of lipid metabolic process  
    involved_in sprouting angiogenesis  
    involved_in sprouting angiogenesis  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in xenophagy  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in lipid droplet  
    is_active_in nucleolus  
    located_in nucleolus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF213
    Names
    protein ALO17
    NP_001414610.1
    XP_038943469.1
    XP_038943470.1
    XP_038943471.1
    XP_063125317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427681.1NP_001414610.1  E3 ubiquitin-protein ligase RNF213

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AKP6, F1M0R1
      Related
      ENSRNOP00000049006.7, ENSRNOT00000044983.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105154873..105254148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087541.2XP_038943469.1  E3 ubiquitin-protein ligase RNF213 isoform X1

      UniProtKB/TrEMBL
      F1M0R1
      Conserved Domains (5) summary
      smart00382
      Location:24272549
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:39314039
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:40004038
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:329
      DZR; Double zinc ribbon
      cl17238
      Location:40004039
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_039087542.2XP_038943470.1  E3 ubiquitin-protein ligase RNF213 isoform X2

      UniProtKB/TrEMBL
      F1M0R1
      Related
      ENSRNOP00000104006.1, ENSRNOT00000142479.1
      Conserved Domains (5) summary
      smart00382
      Location:24272549
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:39304038
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:39994037
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:329
      DZR; Double zinc ribbon
      cl17238
      Location:39994038
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. XM_039087543.2XP_038943471.1  E3 ubiquitin-protein ligase RNF213 isoform X3

      UniProtKB/TrEMBL
      F1M0R1
      Related
      ENSRNOP00000095018.2, ENSRNOT00000109296.2
      Conserved Domains (5) summary
      smart00382
      Location:23842506
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:38883996
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:39573995
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:329
      DZR; Double zinc ribbon
      cl17238
      Location:39573996
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    4. XM_063269247.1XP_063125317.1  E3 ubiquitin-protein ligase RNF213 isoform X1

      UniProtKB/TrEMBL
      F1M0R1

    RNA

    1. XR_005490584.2 RNA Sequence

    2. XR_005490583.2 RNA Sequence

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