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    Fam162a family with sequence similarity 162, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360721, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fam162aprovided by RGD
    Official Full Name
    family with sequence similarity 162, member Aprovided by RGD
    Primary source
    RGD:1590883
    See related
    EnsemblRapid:ENSRNOG00000002255 AllianceGenome:RGD:1590883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human FAM162A (family with sequence similarity 162 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1534.1), Muscle (RPKM 486.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fam162a in Genome Data Viewer
    Location:
    11q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78186260..78215186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64680978..64709865)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67618683..67646253)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481076 Neighboring gene ribosomal protein S2, pseudogene 8 Neighboring gene RAN binding protein 1 like 1 Neighboring gene mitochondrial matrix import factor 23 Neighboring gene WD repeat domain 5B Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC134481077

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC116101

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol  
    located_in membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    protein FAM162A
    Names
    E2-induced gene 5 protein homolog
    growth and transformation-dependent protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399276.2NP_001386205.1  protein FAM162A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q4QQV3
      UniProtKB/TrEMBL
      A0A8I6AP17, A6IRE2
      Related
      ENSRNOP00000096204.2, ENSRNOT00000099640.2
      Conserved Domains (1) summary
      pfam06388
      Location:16134
      DUF1075; Protein of unknown function (DUF1075)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78186260..78215186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270641.1XP_063126711.1  protein FAM162A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR27
      Related
      ENSRNOP00000081032.1, ENSRNOT00000116350.2

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