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    Snx3 sorting nexin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx3provided by RGD
    Official Full Name
    sorting nexin 3provided by RGD
    Primary source
    RGD:1595151
    See related
    EnsemblRapid:ENSRNOG00000046705 AllianceGenome:RGD:1595151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity; protein phosphatase binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; intralumenal vesicle formation; and negative regulation of transport. Predicted to act upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 355.3), Kidney (RPKM 352.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx3 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (47574051..47607577)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45992446..46025361)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (47225382..47263390)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene forkhead box O3 Neighboring gene AFG1 like ATPase Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene nuclear receptor subfamily 2, group E, member 1 Neighboring gene osteoclastogenesis associated transmembrane protein 1 Neighboring gene uncharacterized LOC134483933

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Braun V, et al. Cell Microbiol, 2010 Sep 1. PMID 20482551
    2. SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells. Chua RY, et al. Immunology, 2013 May. PMID 23237080, Free PMC Article
    3. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Xu Y, et al. Nat Cell Biol, 2001 Jul. PMID 11433298
    4. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Mizutani R, et al. Cell Signal, 2009 Nov. PMID 19576982
    5. Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2. Dong H, et al. Acta Biochim Biophys Sin (Shanghai), 2007 Jul. PMID 17622474

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retromer complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intralumenal vesicle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in late endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane invagination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein to membrane docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein to membrane docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transferrin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early phagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044283.1 → NP_001037748.1  sorting nexin-3

      See identical proteins and their annotated locations for NP_001037748.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107918
      UniProtKB/Swiss-Prot
      Q5U211
      UniProtKB/TrEMBL
      A6K6Y8
      Related
      ENSRNOP00000087527.2, ENSRNOT00000075924.3
      Conserved Domains (1) summary
      cd07293
      Location:28 → 150
      PX_SNX3; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      47574051..47607577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099063.2 → XP_038954991.1  sorting nexin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A603, B0BMY2
      Related
      ENSRNOP00000092005.2, ENSRNOT00000074532.5
      Conserved Domains (1) summary
      cl02563
      Location:28 → 129
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_039099064.2 → XP_038954992.1  sorting nexin-3 isoform X2

      Conserved Domains (1) summary
      cl02563
      Location:28 → 86
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U211.1 GenPept UniProtKB/Swiss-Prot:Q5U211

    Gene LinkOut

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