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    Zfp91 zinc finger protein 91 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246282, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp91provided by RGD
    Official Full Name
    zinc finger protein 91provided by RGD
    Primary source
    RGD:628736
    See related
    EnsemblRapid:ENSRNOG00000012524 AllianceGenome:RGD:628736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in activation of NF-kappaB-inducing kinase activity; protein K63-linked ubiquitination; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 406.5), Heart (RPKM 360.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zfp91 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219316002..219353654, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209891344..209928890, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229602499..229640906, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase-like 2 Neighboring gene ciliary neurotrophic factor Neighboring gene leupaxin Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 5 subfamily B member 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZFP91
    Names
    cocaine attenuated zinc-finger protein
    NP_001162591.1
    XP_006231189.1
    XP_063137076.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169120.1NP_001162591.1  E3 ubiquitin-protein ligase ZFP91

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AEZ3, F1MAJ8
      Related
      ENSRNOP00000016804.5, ENSRNOT00000016804.8
      Conserved Domains (3) summary
      sd00017
      Location:345364
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:384409
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:311388
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      219316002..219353654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231127.5XP_006231189.1  E3 ubiquitin-protein ligase ZFP91 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:236255
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:275300
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:202279
      zf-C2H2_8; C2H2-type zinc ribbon
    2. XM_063281006.1XP_063137076.1  E3 ubiquitin-protein ligase ZFP91 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEZ3
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