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    Foxo1 forkhead box O1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84482, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxo1provided by RGD
    Official Full Name
    forkhead box O1provided by RGD
    Primary source
    RGD:620283
    See related
    EnsemblRapid:ENSRNOG00000013397 AllianceGenome:RGD:620283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fkhr; Foxo1a
    Summary
    Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of DNA-templated transcription. Located in cytoplasm. Used to study metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 114.1), Spleen (RPKM 98.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Foxo1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (138462974..138541420)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (136312168..136390603)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (141451234..141527016)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mastermind-like transcriptional coactivator 3 Neighboring gene uncharacterized LOC134485617 Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 3 Neighboring gene cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like Neighboring gene uncharacterized LOC134485910 Neighboring gene uncharacterized LOC102546847

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables beta-catenin binding  
    enables chromatin DNA binding  
    enables nucleic acid binding  
    enables promoter-specific chromatin binding  
    enables protein phosphatase 2A binding  
    enables protein phosphatase 2A binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables transcription coactivator binding PubMed 
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in autophagy  
    acts_upstream_of_or_within blood vessel development  
    acts_upstream_of canonical Wnt signaling pathway  
    involved_in cell differentiation  
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hyperoxia  
    involved_in cellular response to hyperoxia  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to nitric oxide  
    involved_in cellular response to nitric oxide  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in enamel mineralization PubMed 
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within glucose homeostasis  
    involved_in insulin receptor signaling pathway  
    acts_upstream_of_or_within insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress PubMed 
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of stress-activated MAPK cascade  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within neuronal stem cell population maintenance  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of complement-dependent cytotoxicity  
    acts_upstream_of_or_within positive regulation of gluconeogenesis  
    involved_in positive regulation of gluconeogenesis  
    involved_in positive regulation of gluconeogenesis  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of smooth muscle cell apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of gluconeogenesis  
    acts_upstream_of_or_within regulation of neural precursor cell proliferation  
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription initiation by RNA polymerase II PubMed 
    involved_in response to fatty acid  
    involved_in response to fatty acid  
    involved_in response to fluoride PubMed 
    involved_in response to insulin PubMed 
    acts_upstream_of_or_within response to insulin  
    Items 1 - 25 of 69
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    forkhead box protein O1
    Names
    Forkhead box protein O1A
    Forkhead in rhabdomyosarcoma
    forkhead box O1A (rhabdomyosarcoma)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191846.3NP_001178775.1  forkhead box protein O1

      See identical proteins and their annotated locations for NP_001178775.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      G3V7R4
      Related
      ENSRNOP00000018244.3, ENSRNOT00000018244.7
      Conserved Domains (3) summary
      cd00059
      Location:154234
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16675
      Location:417494
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:591627
      FOXO-TAD; Transactivation domain of FOXO protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      138462974..138541420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103268.2XP_038959196.1  forkhead box protein O1 isoform X1

      Conserved Domains (2) summary
      pfam16675
      Location:186259
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:360396
      FOXO-TAD; Transactivation domain of FOXO protein family
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