Ano3 anoctamin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ano3provided by RGD
Official Full Name: anoctamin 3provided by RGD
Primary source: RGD:1308873
See related: EnsemblRapid:ENSRNOG00000004731 AllianceGenome:RGD:1308873
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem16c
Summary: Predicted to enable chloride channel activity and phospholipid scramblase activity. Involved in detection of mechanical stimulus and detection of temperature stimulus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 215.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q34

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (117690242..118004695, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (97235671..97550090, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (101843516..102203368, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
Title: TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
This study thus reveals that TMEM16C enhances K(Na) channel activity in DRG neurons and regulates the processing of pain messages.
Title: TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.

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General gene information

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Markers

D3Mco33 (e-PCR)
- UniSTS:239927

RH141936 (e-PCR)
- UniSTS:223927

D3Rat24 (e-PCR)
- UniSTS:118764

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium activated galactosylceramide scrambling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anoctamin-3

Names: transmembrane protein 16C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430402.1 → NP_001417331.1 anoctamin-3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F1M0A0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

117690242..118004695 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106460.2 → XP_038962388.1 anoctamin-3 isoform X1

Related

ENSRNOP00000006349.7, ENSRNOT00000006349.8

Conserved Domains (2) summary

pfam04547
Location:384 → 949

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:157 → 381

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_039106461.2 → XP_038962389.1 anoctamin-3 isoform X2

Conserved Domains (2) summary

pfam04547
Location:238 → 803

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:11 → 235

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin