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    Nlk nemo like kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497961, updated on 27-Dec-2024

    Summary

    Official Symbol
    Nlkprovided by RGD
    Official Full Name
    nemo like kinaseprovided by RGD
    Primary source
    RGD:1561602
    See related
    EnsemblRapid:ENSRNOG00000071257 AllianceGenome:RGD:1561602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561602
    Summary
    Predicted to enable several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including protein stabilization; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Biomarker of myocardial infarction. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 166.6), Brain (RPKM 158.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nlk in Genome Data Viewer
    Location:
    10q25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63965432..64089006, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63467388..63590960, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65840052..65963932, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene transmembrane protein 97 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene cyclin Q Neighboring gene LYR motif containing 9 like 1 Neighboring gene LYR motif containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables DNA-binding transcription factor binding  
    enables JUN kinase activity  
    enables MAP kinase activity  
    enables MAP kinase activity  
    enables SH2 domain binding  
    enables magnesium ion binding  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in Wnt signaling pathway  
    involved_in cellular response to osmotic stress  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of Wnt signaling pathway  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of receptor signaling pathway via STAT  
    acts_upstream_of_or_within protein autophosphorylation  
    involved_in protein phosphorylation  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of DNA-templated transcription  
    involved_in transforming growth factor beta receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    serine/threonine-protein kinase NLK
    NP_001178853.1
    XP_038942542.1
    XP_063125709.1
    XP_063125710.1
    XP_063125711.1
    XP_063125712.1
    XP_063125713.1
    XP_063125714.1
    XP_063125715.1
    XP_063125716.1
    XP_063125718.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191924.3NP_001178853.1  serine/threonine-protein kinase NLK

      See identical proteins and their annotated locations for NP_001178853.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZSZ3
      UniProtKB/TrEMBL
      A0A8I6AN12
      Related
      ENSRNOP00000098263.1, ENSRNOT00000120628.2
      Conserved Domains (1) summary
      cd07853
      Location:137508
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63965432..64089006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086614.2XP_038942542.1  serine/threonine-protein kinase NLK isoform X1

      UniProtKB/Swiss-Prot
      D3ZSZ3
      UniProtKB/TrEMBL
      A0A8I6AN12
      Conserved Domains (1) summary
      cd07853
      Location:137508
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    2. XM_063269645.1XP_063125715.1  serine/threonine-protein kinase NLK isoform X3

    3. XM_063269644.1XP_063125714.1  serine/threonine-protein kinase NLK isoform X3

    4. XM_063269646.1XP_063125716.1  serine/threonine-protein kinase NLK isoform X4

    5. XM_063269643.1XP_063125713.1  serine/threonine-protein kinase NLK isoform X3

    6. XM_063269641.1XP_063125711.1  serine/threonine-protein kinase NLK isoform X3

    7. XM_063269640.1XP_063125710.1  serine/threonine-protein kinase NLK isoform X3

    8. XM_063269642.1XP_063125712.1  serine/threonine-protein kinase NLK isoform X3

    9. XM_063269639.1XP_063125709.1  serine/threonine-protein kinase NLK isoform X2

      UniProtKB/TrEMBL
      A6HH68
    10. XM_063269648.1XP_063125718.1  serine/threonine-protein kinase NLK isoform X5

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