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    Zfat zinc finger and AT hook domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfatprovided by RGD
    Official Full Name
    zinc finger and AT hook domain containingprovided by RGD
    Primary source
    RGD:1310886
    See related
    EnsemblRapid:ENSRNOG00000025140 AllianceGenome:RGD:1310886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfat1; Zfp406
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; positive regulation of transcription by RNA polymerase II; and spongiotrophoblast layer development. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autoimmune thyroiditis. Orthologous to human ZFAT (zinc finger and AT-hook domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 53.3), Thymus (RPKM 32.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfat in Genome Data Viewer
    Location:
    7q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (101775916..101951135, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (99886954..100054288, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (109037777..109207511, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K, pseudogene 1 Neighboring gene NOP2 nucleolar protein, pseudogene 3 Neighboring gene uncharacterized LOC120093680 Neighboring gene uncharacterized LOC102551574 Neighboring gene microRNA 30b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Tsunoda T, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660741, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spongiotrophoblast layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZFAT
    Names
    ZFAT zinc finger 1
    zinc finger protein 406

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134957.2 → NP_001128429.1  zinc finger protein ZFAT isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A2U0
      Conserved Domains (3) summary
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:264 → 286
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:278 → 300
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001414958.1 → NP_001401887.1  zinc finger protein ZFAT isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000059224.3, ENSRNOT00000068291.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      101775916..101951135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241713.5 → XP_006241775.1  zinc finger protein ZFAT isoform X1

      UniProtKB/TrEMBL
      D4A2U0
      Conserved Domains (3) summary
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:270 → 292
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:284 → 306
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017594961.3 → XP_017450450.1  zinc finger protein ZFAT isoform X2

      UniProtKB/TrEMBL
      A6HRT5

    3. XM_039079527.2 → XP_038935455.1  zinc finger protein ZFAT isoform X3

      Conserved Domains (4) summary
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:270 → 292
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:284 → 308
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:298 → 322
      zf-H2C2_5; C2H2-type zinc-finger domain

    RNA

    1. XR_005486668.2 RNA Sequence

    2. XR_005486669.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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