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    Entpd8 ectonucleoside triphosphate diphosphohydrolase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 613267, updated on 9-Dec-2024

    Summary

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    Symbol
    Entpd8provided by RGD
    Full Name
    ectonucleoside triphosphate diphosphohydrolase 8provided by RGD
    Primary source
    RGD:1561793
    See related
    EnsemblRapid:ENSRNOG00000009239 AllianceGenome:RGD:1561793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 70.2), Uterus (RPKM 5.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Entpd8 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28283392..28295686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7885277..7895517)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2286363..2299720)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene glutathione S-transferase pi 1, pseudogene 3 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene NADPH oxidase activator 1 Neighboring gene uncharacterized LOC134486058 Neighboring gene Notch-regulated ankyrin repeat protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of expressed human ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and its soluble extracellular domain. Knowles AF, et al. Biochemistry, 2006 Jun 13. PMID 16752921
    2. Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8. Bigonnesse F, et al. Biochemistry, 2004 May 11. PMID 15122917
    3. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Fausther M, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Mar. PMID 17095758, Free PMC Article
    4. Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Kukulski F, et al. Purinergic Signal, 2005 Jun. PMID 18404504, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTPDase8 is the canalicular ecto-ATPase/ATPDase and is responsible for the main hepatic NTPDase activity.
      Title: Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables apyrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside monophosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 8
    Names
    E-NTPDase 8
    NTPDase 8
    NTPDase8
    NP_001028737.2
    XP_006233701.1
    XP_038961703.1
    XP_063140549.1
    XP_063140550.1
    XP_063140551.1
    XP_063140552.1
    XP_063140553.1
    XP_063140554.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033565.2 → NP_001028737.2  ectonucleoside triphosphate diphosphohydrolase 8

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5DRK1
      Related
      ENSRNOP00000012289.7, ENSRNOT00000012289.9
      Conserved Domains (1) summary
      cl17037
      Location:34 → 454
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28283392..28295686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284483.1 → XP_063140553.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

      UniProtKB/Swiss-Prot
      Q5DRK1

    2. XM_063284484.1 → XP_063140554.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4

      UniProtKB/Swiss-Prot
      Q5DRK1

    3. XM_063284479.1 → XP_063140549.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5DRK1

    4. XM_039105775.2 → XP_038961703.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5DRK1
      Conserved Domains (1) summary
      cl17037
      Location:34 → 459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. XM_006233639.4 → XP_006233701.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

      See identical proteins and their annotated locations for XP_006233701.1

      UniProtKB/Swiss-Prot
      Q5DRK1
      Conserved Domains (1) summary
      cl17037
      Location:34 → 459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    6. XM_063284481.1 → XP_063140551.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

      UniProtKB/Swiss-Prot
      Q5DRK1

    7. XM_063284482.1 → XP_063140552.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

      UniProtKB/Swiss-Prot
      Q5DRK1

    8. XM_063284480.1 → XP_063140550.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

      UniProtKB/Swiss-Prot
      Q5DRK1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DRK1.1 GenPept UniProtKB/Swiss-Prot:Q5DRK1

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