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    Rpain RPA interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287463, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpainprovided by RGD
    Official Full Name
    RPA interacting proteinprovided by RGD
    Primary source
    RGD:1308492
    See related
    EnsemblRapid:ENSRNOG00000006913 AllianceGenome:RGD:1308492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308492
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within response to UV. Predicted to be located in PML body; cytoplasm; and fibrillar center. Predicted to be active in nucleus. Orthologous to human RPAIN (RPA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 91.3), Testes (RPKM 76.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rpain in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (56190975..56198490)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55692410..55699910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57606287..57613834)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 18 Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene nucleoporin 88 Neighboring gene complement C1q binding protein Neighboring gene DEAH-box helicase 33

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in PML body  
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    RPA-interacting protein
    Names
    RAP interaction protein alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033060.2NP_001028232.2  RPA-interacting protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4G2Y1
      UniProtKB/TrEMBL
      A0A8I6ASS9, A6HGA9
      Related
      ENSRNOP00000097917.2, ENSRNOT00000101989.2
      Conserved Domains (3) summary
      pfam14766
      Location:846
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59127
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137217
      RPA_interact_C; Replication protein A interacting C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      56190975..56198490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268664.1XP_063124734.1  RPA-interacting protein isoform X1

    2. XM_039085489.2XP_038941417.1  RPA-interacting protein isoform X2

      Conserved Domains (2) summary
      pfam14766
      Location:844
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14768
      Location:43118
      RPA_interact_C; Replication protein A interacting C-terminal
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