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    Pcbp3 poly(rC) binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294336, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pcbp3provided by RGD
    Official Full Name
    poly(rC) binding protein 3provided by RGD
    Primary source
    RGD:1307430
    See related
    EnsemblRapid:ENSRNOG00000001245 AllianceGenome:RGD:1307430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C-rich single-stranded DNA binding activity and mRNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human PCBP3 (poly(rC) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 84.0), Thymus (RPKM 62.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pcbp3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (11635579..11877721)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (11678218..11878210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (12429255..12629985)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene collagen type XVIII alpha 1 chain Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 5 Neighboring gene solute carrier family 19 member 1 Neighboring gene adenosylhomocysteinase, pseudogene 1 Neighboring gene uncharacterized LOC120098922 Neighboring gene collagen type VI alpha 1 chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-rich single-stranded DNA binding  
    enables mRNA binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011945.2NP_001011945.2  poly(rC)-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      BC079196, JAXUCZ010000020
      UniProtKB/TrEMBL
      F7F4P9
      Conserved Domains (3) summary
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:266340
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      11635579..11877721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279058.1XP_063135128.1  poly(rC)-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y0N5, A6JKB2
      Related
      ENSRNOP00000077332.2, ENSRNOT00000104059.2
    2. XM_039098578.2XP_038954506.1  poly(rC)-binding protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y0N5
      Conserved Domains (3) summary
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:285359
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:38114
      KH-I; K homology (KH) RNA-binding domain, type I
    3. XM_039098577.2XP_038954505.1  poly(rC)-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y0N5, A6JKB2
      Related
      ENSRNOP00000102769.1, ENSRNOT00000159135.1
      Conserved Domains (3) summary
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:38114
      KH-I; K homology (KH) RNA-binding domain, type I
    4. XM_039098572.2XP_038954500.1  poly(rC)-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0N5
      Conserved Domains (4) summary
      pfam03154
      Location:181314
      Atrophin-1; Atrophin-1 family
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:308382
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    5. XM_006256283.5XP_006256345.1  poly(rC)-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006256345.1

      UniProtKB/TrEMBL
      A0A8I5Y0N5
      Conserved Domains (4) summary
      pfam03154
      Location:181315
      Atrophin-1; Atrophin-1 family
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:309383
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    6. XM_039098575.2XP_038954503.1  poly(rC)-binding protein 3 isoform X3

      UniProtKB/TrEMBL
      F7F4P9
      Related
      ENSRNOP00000001675.6, ENSRNOT00000001675.6
      Conserved Domains (3) summary
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:289363
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    7. XM_039098576.2XP_038954504.1  poly(rC)-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      F7F4P9
      Conserved Domains (4) summary
      pfam03154
      Location:181298
      Atrophin-1; Atrophin-1 family
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:288362
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    8. XM_039098580.2XP_038954508.1  poly(rC)-binding protein 3 isoform X9

      UniProtKB/TrEMBL
      F7F4P9
      Conserved Domains (3) summary
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:265339
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:38114
      KH-I; K homology (KH) RNA-binding domain, type I
    9. XM_063279064.1XP_063135134.1  poly(rC)-binding protein 3 isoform X12

    10. XM_063279065.1XP_063135135.1  poly(rC)-binding protein 3 isoform X14

    11. XM_063279062.1XP_063135132.1  poly(rC)-binding protein 3 isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y0N5
    12. XM_063279063.1XP_063135133.1  poly(rC)-binding protein 3 isoform X11

    13. XM_039098583.2XP_038954511.1  poly(rC)-binding protein 3 isoform X13

      Conserved Domains (2) summary
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    14. XM_039098585.2XP_038954513.1  poly(rC)-binding protein 3 isoform X16

      Conserved Domains (2) summary
      cd22516
      Location:38114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
    15. XM_039098584.2XP_038954512.1  poly(rC)-binding protein 3 isoform X15

      Conserved Domains (2) summary
      cd22519
      Location:125202
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:38114
      KH-I; K homology (KH) RNA-binding domain, type I
    16. XM_063279056.1XP_063135126.1  poly(rC)-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0N5
      Related
      ENSRNOP00000076709.2, ENSRNOT00000103785.2
    17. XM_063279057.1XP_063135127.1  poly(rC)-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y0N5, A6JKB2
      Related
      ENSRNOP00000082318.2, ENSRNOT00000098898.2
    18. XM_063279061.1XP_063135131.1  poly(rC)-binding protein 3 isoform X8

      UniProtKB/TrEMBL
      F7F4P9
    19. XM_063279059.1XP_063135129.1  poly(rC)-binding protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y0N5
    20. XM_063279060.1XP_063135130.1  poly(rC)-binding protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWT0

    RNA

    1. XR_010060648.1 RNA Sequence

    2. XR_005497206.2 RNA Sequence

    3. XR_010060649.1 RNA Sequence

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