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    Maf MAF bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54267, updated on 9-Dec-2024

    Summary

    Symbol
    Mafprovided by RGD
    Full Name
    MAF bZIP transcription factorprovided by RGD
    Primary source
    RGD:3034
    See related
    EnsemblRapid:ENSRNOG00000012428 AllianceGenome:RGD:3034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Maf2; cMaf
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 250.2), Muscle (RPKM 110.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Maf in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (60259200..60622145, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (43353867..43713162, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (48179826..48200995, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene WW domain-containing oxidoreductase Neighboring gene uncharacterized LOC120098538 Neighboring gene uncharacterized LOC108348984 Neighboring gene uncharacterized LOC134483377 Neighboring gene uncharacterized LOC102547452 Neighboring gene uncharacterized LOC108348942

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables double-stranded DNA binding PubMed 
    enables identical protein binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables protein-containing complex binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables sequence-specific double-stranded DNA binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell development  
    involved_in inner ear development  
    acts_upstream_of_or_within inner ear development  
    acts_upstream_of_or_within lens development in camera-type eye  
    involved_in lens fiber cell differentiation  
    involved_in lens fiber cell differentiation  
    acts_upstream_of_or_within lens fiber cell differentiation  
    involved_in megakaryocyte differentiation  
    involved_in megakaryocyte differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of chondrocyte differentiation  
    acts_upstream_of_or_within regulation of chondrocyte differentiation  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    transcription factor Maf
    Names
    C-Maf
    bZip transcription factor c-maf
    proto-oncogene c-maf
    transcription factor Maf-2
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019318.2NP_062191.2  transcription factor Maf

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P54844
      Conserved Domains (2) summary
      cd14718
      Location:279347
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86119
      Maf_N; Maf N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      60259200..60622145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097958.2XP_038953886.1  transcription factor Maf isoform X2

      UniProtKB/Swiss-Prot
      P54844
      UniProtKB/TrEMBL
      F1LSV1
      Conserved Domains (2) summary
      cd14718
      Location:279347
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86119
      Maf_N; Maf N-terminal region
    2. XM_039097956.2XP_038953884.1  transcription factor Maf isoform X1

      UniProtKB/Swiss-Prot
      P54844
      Related
      ENSRNOP00000101124.1, ENSRNOT00000153831.1
      Conserved Domains (2) summary
      cd14718
      Location:279347
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86119
      Maf_N; Maf N-terminal region
    3. XM_039097957.2XP_038953885.1  transcription factor Maf isoform X2

      UniProtKB/Swiss-Prot
      P54844
      UniProtKB/TrEMBL
      F1LSV1
      Conserved Domains (2) summary
      cd14718
      Location:279347
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86119
      Maf_N; Maf N-terminal region
    4. XM_063278262.1XP_063134332.1  transcription factor Maf isoform X2

      UniProtKB/Swiss-Prot
      P54844
      UniProtKB/TrEMBL
      F1LSV1
      Related
      ENSRNOP00000016577.4, ENSRNOT00000016577.7
    5. XM_006255696.5XP_006255758.1  transcription factor Maf isoform X3

      UniProtKB/Swiss-Prot
      P54844
      UniProtKB/TrEMBL
      A0A8I6B690
      Related
      ENSRNOP00000100324.1, ENSRNOT00000164218.1
      Conserved Domains (2) summary
      cd14718
      Location:279347
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:86119
      Maf_N; Maf N-terminal region

    RNA

    1. XR_010060025.1 RNA Sequence

    2. XR_010060024.1 RNA Sequence

    3. XR_010060023.1 RNA Sequence

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