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    Coil coilin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50998, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coilprovided by RGD
    Official Full Name
    coilinprovided by RGD
    Primary source
    RGD:62031
    See related
    EnsemblRapid:ENSRNOG00000000244 AllianceGenome:RGD:62031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable disulfide oxidoreductase activity; identical protein binding activity; and snRNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in cytosol and nucleus. Predicted to be active in Cajal body. Orthologous to human COIL (coilin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 231.0), Brain (RPKM 57.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Coil in Genome Data Viewer
    Location:
    10q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74286279..74307597)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73789077..73810378)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76320676..76336169)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene elongin B like 3 Neighboring gene TATA-box binding protein associated factor 11 like 1 Neighboring gene tripartite motif-containing 25 Neighboring gene uncharacterized LOC120095172 Neighboring gene diacylglycerol kinase epsilon

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U1 snRNA binding  
    enables U2 snRNA binding  
    enables disulfide oxidoreductase activity  
    enables identical protein binding  
    Process Evidence Code Pubs
    involved_in spliceosomal snRNP assembly  
    Component Evidence Code Pubs
    is_active_in Cajal body  
    located_in Cajal body  
    located_in cytosol  
    located_in cytosol  
    located_in female germ cell nucleus  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nuclear body  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017360.2NP_059056.2  coilin

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZUZ7, A6HHZ5
      Related
      ENSRNOP00000082470.1, ENSRNOT00000110927.2
      Conserved Domains (1) summary
      pfam15862
      Location:7138
      Coilin_N; Coilin N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      74286279..74307597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086664.2XP_038942592.1  coilin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUZ7, A6HHZ5, E9PTJ1
      Related
      ENSRNOP00000030534.6, ENSRNOT00000037693.8
      Conserved Domains (1) summary
      pfam15862
      Location:10141
      Coilin_N; Coilin N-terminus
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