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    Sh3bp1 SH3-domain binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300067, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh3bp1provided by RGD
    Official Full Name
    SH3-domain binding protein 1provided by RGD
    Primary source
    RGD:1306275
    See related
    EnsemblRapid:ENSRNOG00000009360 AllianceGenome:RGD:1306275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase activator activity. Involved in cell migration; filopodium assembly; and positive regulation of GTPase activity. Located in cell leading edge. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 161.9), Spleen (RPKM 78.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Sh3bp1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112338087..112350659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110457626..110470201)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120125747..120138148)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479608 Neighboring gene uncharacterized LOC120093687 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene uncharacterized LOC134479755 Neighboring gene pyridoxal phosphatase Neighboring gene galectin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables SH3 domain binding  
    enables semaphorin receptor binding  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament organization  
    involved_in cell junction assembly  
    involved_in cell junction assembly  
    involved_in cell migration PubMed 
    involved_in cell migration  
    involved_in cell migration  
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in filopodium assembly PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction  
    involved_in negative regulation of small GTPase mediated signal transduction  
    involved_in negative regulation of small GTPase mediated signal transduction  
    involved_in phagocytosis, engulfment  
    involved_in phagocytosis, engulfment  
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of GTPase activity  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin filament depolymerization  
    involved_in regulation of blood vessel endothelial cell migration  
    involved_in ruffle assembly  
    involved_in semaphorin-plexin signaling pathway  
    involved_in semaphorin-plexin signaling pathway  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in adherens junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in cell leading edge PubMed 
    located_in cell leading edge  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    part_of exocyst  
    part_of exocyst  
    located_in lamellipodium  
    located_in nucleus  
    located_in nucleus  
    located_in phagocytic cup  
    located_in phagocytic cup  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    SH3 domain-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171981.1NP_001165452.1  SH3 domain-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      D3ZFJ3
      Related
      ENSRNOP00000012480.3, ENSRNOT00000012480.7
      Conserved Domains (2) summary
      cd07620
      Location:16275
      BAR_SH3BP1; The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1
      cl02570
      Location:272473
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112338087..112350659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263317.1XP_063119387.1  SH3 domain-binding protein 1 isoform X1

    2. XM_039078835.2XP_038934763.1  SH3 domain-binding protein 1 isoform X1

      Conserved Domains (2) summary
      cl02570
      Location:208409
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:1211
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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