Ogn osteoglycin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ognprovided by RGD
Full Name: osteoglycinprovided by RGD
Primary source: RGD:1308171
See related: EnsemblRapid:ENSRNOG00000029792 AllianceGenome:RGD:1308171
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable growth factor activity. Involved in negative regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular matrix. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 851.8), Lung (RPKM 538.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (15238500..15259167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (15032069..15052626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (14607442..14628274, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
Title: Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
Study reveals that Ogn is post-transcriptionally regulated by miR-155 in the maintenance of the cardiac cell morphology in physiological and pathological conditions.
Title: Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts.
concluded that down-regulation of mimecan was involved in aortic hypertrophy induced by sinoaortic denervation in rats
Title: Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats.
These data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
Title: Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in articular cartilage development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mimecan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106103.1 → NP_001099573.1 mimecan precursor

See identical proteins and their annotated locations for NP_001099573.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A6J6V8, D3ZVB7

Related

ENSRNOP00000020532.5, ENSRNOT00000020532.9

Conserved Domains (2) summary

sd00033
Location:123 → 144

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:143 → 225

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

15238500..15259167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771490.4 → XP_008769712.1 mimecan isoform X1

See identical proteins and their annotated locations for XP_008769712.1

UniProtKB/TrEMBL

A0A1W2Q6Q0

Related

ENSRNOP00000110107.1, ENSRNOT00000171835.1

Conserved Domains (4) summary

cd00116
Location:249 → 352

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:229 → 250

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:249 → 331

LRR_8; Leucine rich repeat

pfam15376
Location:167 → 264

DUF4603; Domain of unknown function (DUF4603)
XM_063276149.1 → XP_063132219.1 mimecan isoform X1

UniProtKB/TrEMBL

A0A1W2Q6Q0