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    Kcnc4 potassium voltage-gated channel subfamily C member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684516, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnc4provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily C member 4provided by RGD
    Primary source
    RGD:1589169
    See related
    EnsemblRapid:ENSRNOG00000060988 AllianceGenome:RGD:1589169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and voltage-gated potassium channel activity. Involved in negative regulation of neuronal action potential and nervous system development. Located in several cellular components, including cell surface; neuronal cell body; and synaptic vesicle. Is active in several cellular components, including calyx of Held; glycinergic synapse; and synaptic membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 149.6), Brain (RPKM 50.9) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Kcnc4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (197747095..197788467, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195063967..195100244, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210220908..210241447, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3, pseudogene 3 Neighboring gene uncharacterized LOC134485669 Neighboring gene solute carrier family 6 member 17 Neighboring gene ubiquitin-like 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables voltage-gated potassium channel activity PubMed 
    enables voltage-gated potassium channel activity  
    enables voltage-gated potassium channel activity  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in axon terminus  
    located_in axon terminus  
    is_active_in calyx of Held PubMed 
    located_in cell surface PubMed 
    located_in dendrite PubMed 
    is_active_in dendrite membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glycinergic synapse PubMed 
    located_in neuromuscular junction  
    located_in neuron projection  
    located_in neuronal cell body PubMed 
    is_active_in neuronal cell body membrane  
    located_in postsynapse PubMed 
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    is_active_in presynaptic membrane PubMed 
    located_in synaptic vesicle PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    voltage-gated potassium channel KCNC4; potassium voltage-gated channel subfamily C member 4
    Names
    potassium channel, voltage gated Shaw-related subfamily C, member 4
    potassium voltage gated channel, Shaw-related subfamily, member 4
    potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3)
    raw3
    voltage-gated potassium channel subunit Kv3.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122776.2NP_001116248.2  voltage-gated potassium channel KCNC4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q63734
      Related
      ENSRNOP00000087803.2, ENSRNOT00000093977.2
    2. NM_001415110.1NP_001402039.1  voltage-gated potassium channel KCNC4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q63734

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      197747095..197788467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103131.2XP_038959059.1  potassium voltage-gated channel subfamily C member 4 isoform X2

      UniProtKB/Swiss-Prot
      Q63734
      UniProtKB/TrEMBL
      A0A0G2JTV8
      Related
      ENSRNOP00000068863.2, ENSRNOT00000086420.3
      Conserved Domains (3) summary
      cd18415
      Location:35159
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:226484
      Ion_trans; Ion transport protein
      pfam11404
      Location:129
      Potassium_chann; Potassium voltage-gated channel
    2. XM_039103129.2XP_038959057.1  potassium voltage-gated channel subfamily C member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q63734
      UniProtKB/TrEMBL
      A0A8I6GGE0
      Related
      ENSRNOP00000100695.1, ENSRNOT00000162236.1
      Conserved Domains (3) summary
      cd18415
      Location:35159
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:226484
      Ion_trans; Ion transport protein
      pfam11404
      Location:129
      Potassium_chann; Potassium voltage-gated channel

    RNA

    1. XR_010063661.1 RNA Sequence

    2. XR_010063660.1 RNA Sequence

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