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    Dcun1d4 defective in cullin neddylation 1 domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360928, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcun1d4provided by RGD
    Official Full Name
    defective in cullin neddylation 1 domain containing 4provided by RGD
    Primary source
    RGD:1310422
    See related
    EnsemblRapid:ENSRNOG00000002152 AllianceGenome:RGD:1310422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310422
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation and protein neddylation. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D4 (defective in cullin neddylation 1 domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 119.1), Testes (RPKM 82.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dcun1d4 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35006792..35087285, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (34652723..34733122, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37210721..37294517, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene sarcoglycan, beta Neighboring gene leucine rich repeat containing 66 Neighboring gene cell wall biogenesis 43 C-terminal homolog Neighboring gene eukaryotic translation initiation factor 5, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding  
    enables cullin family protein binding  
    enables ubiquitin conjugating enzyme binding  
    enables ubiquitin-like protein binding  
    Component Evidence Code Pubs
    located_in nucleus  
    located_in nucleus  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    DCN1-like protein 4
    Names
    DCN1, defective in cullin neddylation 1, domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108359.1NP_001101829.1  DCN1-like protein 4

      See identical proteins and their annotated locations for NP_001101829.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473981
      UniProtKB/TrEMBL
      A0A8I6A381, A6JD31, D4A0F7
      Related
      ENSRNOP00000059462.1, ENSRNOT00000065458.4
      Conserved Domains (1) summary
      pfam03556
      Location:175285
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      35006792..35087285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599288.3XP_017454777.1  DCN1-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUZ4, A0A8I6A381
      Related
      ENSRNOP00000069290.1, ENSRNOT00000081087.3
    2. XM_039092176.2XP_038948104.1  DCN1-like protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:189264
      Cullin_binding; Cullin binding
    3. XM_063273337.1XP_063129407.1  DCN1-like protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B1J8
      Related
      ENSRNOP00000094828.1, ENSRNOT00000102842.2
    4. XM_006250907.5XP_006250969.1  DCN1-like protein 4 isoform X4

      Conserved Domains (1) summary
      pfam03556
      Location:138248
      Cullin_binding; Cullin binding
    5. XM_039092177.2XP_038948105.1  DCN1-like protein 4 isoform X6

      Conserved Domains (1) summary
      pfam03556
      Location:115225
      Cullin_binding; Cullin binding
    6. XM_063273339.1XP_063129409.1  DCN1-like protein 4 isoform X6

    7. XM_063273338.1XP_063129408.1  DCN1-like protein 4 isoform X5

      Related
      ENSRNOP00000106249.1, ENSRNOT00000130847.1
    8. XM_063273340.1XP_063129410.1  DCN1-like protein 4 isoform X7

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