Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mamstrprovided by RGD
Official Full Name: MEF2 activating motif and SAP domain containing transcriptional regulatorprovided by RGD
Primary source: RGD:1588652
See related: EnsemblRapid:ENSRNOG00000024580 AllianceGenome:RGD:1588652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of myotube differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human MAMSTR (MEF2 activating motif and SAP domain containing transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 52.6), Heart (RPKM 13.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105246172..105252759)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96109715..96116295)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101621733..101628379)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI853551 (e-PCR)
- UniSTS:164355

RH128437 (e-PCR)
- UniSTS:211745

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MEF2 activating motif and SAP domain containing transcriptional regulator; MEF2-activating motif and SAP domain-containing transcriptional regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432646.1 → NP_001419575.1 MEF2 activating motif and SAP domain containing transcriptional regulator

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZHU3
NM_001432647.1 → NP_001419576.1 MEF2 activating motif and SAP domain containing transcriptional regulator

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZHU3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105246172..105252759

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001076631.8 → XP_001076631.2 MEF2-activating motif and SAP domain-containing transcriptional regulator

Related

ENSRNOP00000053047.2, ENSRNOT00000029167.9

Conserved Domains (1) summary

pfam02037
Location:166 → 195

SAP; SAP domain
XM_006229211.5 → XP_006229273.1 MEF2-activating motif and SAP domain-containing transcriptional regulator

Related

ENSRNOP00000111984.1, ENSRNOT00000136967.1

Conserved Domains (1) summary

pfam02037
Location:166 → 195

SAP; SAP domain