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    Rac3 Rac family small GTPase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688319, updated on 9-Dec-2024

    Summary

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    Symbol
    Rac3provided by RGD
    Full Name
    Rac family small GTPase 3provided by RGD
    Primary source
    RGD:1590052
    See related
    EnsemblRapid:ENSRNOG00000069600 AllianceGenome:RGD:1590052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity and calcium-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of cell adhesion; postsynaptic actin cytoskeleton organization; and regulation of postsynapse assembly. Predicted to act upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and regulation of neuron maturation. Located in growth cone. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 202.9), Liver (RPKM 67.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rac3 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106501133..106503569)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106002808..106005243)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109903920..109906596)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centromere protein X Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene dicarbonyl and L-xylulose reductase Neighboring gene carbonyl reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. Donnelly SK, et al. J Cell Biol, 2017 Dec 4. PMID 29061650, Free PMC Article
    2. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. Haataja L, et al. J Biol Chem, 2002 Mar 8. PMID 11756406
    3. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe S, et al. Int J Mol Med, 2002 May. PMID 11956649
    4. Rac3-induced neuritogenesis requires binding to Neurabin I. Orioli D, et al. Mol Biol Cell, 2006 May. PMID 16525025, Free PMC Article
    5. WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome. White JJ, et al. Am J Hum Genet, 2018 Jan 4. PMID 29276006, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
      Title: Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neutrophil migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related C3 botulinum toxin substrate 3
    Names
    ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
    NP_001385883.1
    XP_063125945.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398954.1 → NP_001385883.1  ras-related C3 botulinum toxin substrate 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JUG6, A0A0G2K0X4
      Related
      ENSRNOP00000064762.4, ENSRNOT00000073886.4
      Conserved Domains (1) summary
      cd01871
      Location:3 → 176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106501133..106503569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269875.1 → XP_063125945.1  ras-related C3 botulinum toxin substrate 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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