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    Ptpre protein tyrosine phosphatase, receptor type, E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114767, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ptpreprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Eprovided by RGD
    Primary source
    RGD:620771
    See related
    EnsemblRapid:ENSRNOG00000015717 AllianceGenome:RGD:620771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PTPepsilon
    Summary
    Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of insulin receptor signaling pathway. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PTPRE (protein tyrosine phosphatase receptor type E). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 59.8), Spleen (RPKM 52.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpre in Genome Data Viewer
    Location:
    1q41
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (199774195..199924646)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (190344331..190494815)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (207820719..207987123)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485187 Neighboring gene clarin 3 Neighboring gene uncharacterized LOC102551963 Neighboring gene marker of proliferation Ki-67 Neighboring gene uncharacterized LOC134484914

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation. Tanuma N, et al. Eur J Biochem, 1999 Jan. PMID 9914474
    2. Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon. Nakamura K, et al. Biochem Biophys Res Commun, 1996 Jan 26. PMID 8579581
    3. Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells. Shimizu H, et al. Am J Physiol Cell Physiol, 2010 Nov. PMID 20686073
    4. Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Kappert K, et al. Arterioscler Thromb Vasc Biol, 2006 Dec. PMID 16990553
    5. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Akimoto M, et al. Scand J Immunol, 2009 May. PMID 19508371

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that PTPepsilonM negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTPepsilonM may be involved in diabetes-accelerated atherosclerosis.
      Title: Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells.
    2. Antioxidants inhibited neointima formation and reduced PDGF receptor phosphorylation in the neointima and also increased PTP activity.
      Title: Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis.
    3. Data suggest that protein tyrosine phosphatase epsilonM negatively regulates the development of atherosclerosis by activating c-Src.
      Title: Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor protein tyrosine phosphatase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase epsilon
    Names
    R-PTP-epsilon
    protein tyrosine phosphatase epsilon
    protein tyrosine phosphatase epsilon-like 1
    protein tyrosine phosphatase epsilon-like 2
    protein tyrosine phosphatase, receptor type, epsilon
    NP_446219.1
    XP_006230511.1
    XP_006230512.3
    XP_038964618.1
    XP_038964717.1
    XP_063119170.1
    XP_063119306.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053767.3 → NP_446219.1  receptor-type tyrosine-protein phosphatase epsilon precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      B2GV87, Q63476, Q63477
      UniProtKB/TrEMBL
      A0A8L2QB53
      Related
      ENSRNOP00000080854.2, ENSRNOT00000098076.2
      Conserved Domains (2) summary
      cd14620
      Location:164 → 392
      R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
      cl28904
      Location:479 → 688
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      199774195..199924646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108789.2 → XP_038964717.1  receptor-type tyrosine-protein phosphatase epsilon isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:184 → 354
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_039108690.2 → XP_038964618.1  receptor-type tyrosine-protein phosphatase epsilon isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUL6, A0A8L2QB53
      Related
      ENSRNOP00000021359.8, ENSRNOT00000021359.10
      Conserved Domains (2) summary
      cd14620
      Location:184 → 412
      R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
      cl28904
      Location:499 → 708
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_006230449.5 → XP_006230511.1  receptor-type tyrosine-protein phosphatase epsilon isoform X2

      UniProtKB/Swiss-Prot
      B2GV87, Q63476, Q63477
      UniProtKB/TrEMBL
      A0A8L2QB53
      Conserved Domains (2) summary
      cd14620
      Location:164 → 392
      R-PTPc-E-1; catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1
      cl28904
      Location:479 → 688
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_063263100.1 → XP_063119170.1  receptor-type tyrosine-protein phosphatase epsilon isoform X2

      UniProtKB/Swiss-Prot
      B2GV87, Q63476, Q63477
      UniProtKB/TrEMBL
      A0A8L2QB53

    5. XM_006230450.5 → XP_006230512.3  receptor-type tyrosine-protein phosphatase epsilon isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR03, A6HX65
      Related
      ENSRNOP00000078012.1, ENSRNOT00000110825.2

    6. XM_063263236.1 → XP_063119306.1  receptor-type tyrosine-protein phosphatase epsilon isoform X5

    RNA

    1. XR_005503825.2 RNA Sequence

    2. XR_010052952.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV87.1 GenPept UniProtKB/Swiss-Prot:B2GV87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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