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    Rnf5 ring finger protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407784, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rnf5provided by RGD
    Official Full Name
    ring finger protein 5provided by RGD
    Primary source
    RGD:1588458
    See related
    EnsemblRapid:ENSRNOG00000000438 AllianceGenome:RGD:1588458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in protein polyubiquitination and proteolysis involved in protein catabolic process. Predicted to act upstream of or within several processes, including negative regulation of autophagy; protein destabilization; and regulation of autophagosome assembly. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 216.4), Adrenal (RPKM 112.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rnf5 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4150032..4152593)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4145539..4147985)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4366244..4368690, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene PBX homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109637

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables metal ion binding  
    enables protein-containing complex binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-like protein conjugating enzyme binding  
    enables ubiquitin-like protein conjugating enzyme binding  
    enables ubiquitin-protein transferase activity  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in mitochondrial membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF5
    Names
    RING-type E3 ubiquitin transferase RNF5
    ing finger protein 5 pseudogene
    ring finger protein 5, E3 ubiquitin protein ligase
    NP_001102495.1
    XP_063135456.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109025.2NP_001102495.1  E3 ubiquitin-protein ligase RNF5

      See identical proteins and their annotated locations for NP_001102495.1

      Status: VALIDATED

      Source sequence(s)
      BC088341, DY573537
      UniProtKB/Swiss-Prot
      Q5M807
      UniProtKB/TrEMBL
      A6KTG9
      Related
      ENSRNOP00000070056.3, ENSRNOT00000088244.3
      Conserved Domains (2) summary
      PLN03208
      Location:25117
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cd16743
      Location:2570
      RING-HC_RNF5; RING finger, HC subclass, found in RING finger protein 5 (RNF5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4150032..4152593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279386.1XP_063135456.1  E3 ubiquitin-protein ligase RNF5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWX8, A0A8L2UHC5

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