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    Gucy2d guanylate cyclase 2D, retinal [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79222, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gucy2dprovided by RGD
    Official Full Name
    guanylate cyclase 2D, retinalprovided by RGD
    Primary source
    RGD:620438
    See related
    EnsemblRapid:ENSRNOG00000007931 AllianceGenome:RGD:620438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gucy2e; RETGC-1
    Summary
    Enables guanylate cyclase activity and protein homodimerization activity. Involved in cGMP-mediated signaling. Located in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 3.6), Lung (RPKM 1.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Gucy2d in Genome Data Viewer
    Location:
    10q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54453753..54478639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53954918..53975576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55835695..55851235, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene U6 spliceosomal RNA Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GTP binding  
    enables guanylate cyclase activity  
    enables guanylate cyclase activity PubMed 
    enables guanylate cyclase activity  
    enables guanylate cyclase activity  
    enables identical protein binding PubMed 
    enables peptide receptor activity  
    enables protein homodimerization activity PubMed 
    enables protein kinase activity  
    enables protein-containing complex binding PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process  
    involved_in cGMP biosynthetic process  
    involved_in cGMP biosynthetic process  
    involved_in cGMP-mediated signaling PubMed 
    involved_in intracellular signal transduction  
    involved_in receptor guanylyl cyclase signaling pathway  
    involved_in visual perception  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment membrane PubMed 
    located_in photoreceptor outer segment membrane  
    located_in photoreceptor outer segment membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    retinal guanylyl cyclase 1
    Names
    guanylate cyclase 2D, membrane (retina-specific)
    guanylate cyclase 2E
    guanylyl cyclase 2e
    guanylyl cyclase GC-E
    NP_077356.1
    XP_038942841.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024380.1NP_077356.1  retinal guanylyl cyclase 1 precursor

      See identical proteins and their annotated locations for NP_077356.1

      Status: PROVISIONAL

      Source sequence(s)
      L36029
      UniProtKB/Swiss-Prot
      P51840
      UniProtKB/TrEMBL
      A6HFP3, V9GZ79
      Related
      ENSRNOP00000010790.5, ENSRNOT00000010790.6
      Conserved Domains (4) summary
      smart00044
      Location:8481039
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:540814
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      cd06371
      Location:58434
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:823868
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54453753..54478639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086913.2XP_038942841.1  retinal guanylyl cyclase 1 isoform X1

      UniProtKB/Swiss-Prot
      P51840
      UniProtKB/TrEMBL
      A6HFP3, V9GZ79
      Conserved Domains (4) summary
      smart00044
      Location:8481039
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:540814
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      cd06371
      Location:58434
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:823868
      HNOBA; Heme NO binding associated
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