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    Smad9 SMAD family member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85435, updated on 9-Dec-2024

    Summary

    Symbol
    Smad9provided by RGD
    Full Name
    SMAD family member 9provided by RGD
    Primary source
    RGD:71004
    See related
    EnsemblRapid:ENSRNOG00000000091 AllianceGenome:RGD:71004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Madh9; Smad8
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Mullerian duct regression; positive regulation of DNA-templated transcription; and response to hypoxia. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of heteromeric SMAD protein complex. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 33.8), Adrenal (RPKM 23.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Smad9 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141106668..141156477)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (138956326..139006315)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143951725..144002025)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene exosome component 8 Neighboring gene ALG5, dolichyl-phosphate beta-glucosyltransferase Neighboring gene uncharacterized LOC120100820 Neighboring gene regulatory factor X-associated protein Neighboring gene uncharacterized LOC134485734

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables I-SMAD binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables metal ion binding  
    enables protein binding PubMed 
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in Mullerian duct regression PubMed 
    involved_in SMAD protein signal transduction  
    involved_in SMAD protein signal transduction  
    involved_in SMAD protein signal transduction  
    involved_in anatomical structure morphogenesis  
    involved_in bone development  
    acts_upstream_of_or_within bone development  
    involved_in cartilage development  
    acts_upstream_of_or_within cartilage development  
    involved_in cell differentiation  
    involved_in cellular response to organic cyclic compound  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    involved_in hindbrain development  
    acts_upstream_of_or_within hindbrain development  
    involved_in midbrain development  
    acts_upstream_of_or_within midbrain development  
    involved_in osteoblast differentiation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell differentiation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to hypoxia PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in ureteric bud development  
    involved_in ureteric bud development  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    part_of heteromeric SMAD protein complex  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 9
    Names
    MAD homolog 9
    SMAD 9
    mothers against DPP homolog 9
    NP_620227.2
    XP_063138716.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138872.2NP_620227.2  mothers against decapentaplegic homolog 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O54835
      UniProtKB/TrEMBL
      A6JVE0, G3V603
      Related
      ENSRNOP00000000102.1, ENSRNOT00000000102.5
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230430
      MH2; C-terminal Mad Homology 2 (MH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141106668..141156477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282646.1XP_063138716.1  mothers against decapentaplegic homolog 9 isoform X1

      UniProtKB/Swiss-Prot
      O54835
      UniProtKB/TrEMBL
      A6JVE0, G3V603
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